• Most studies investigating cardiomyocyte differentiation

  2018-10-29

  

  Most studies investigating cardiomyocyte differentiation from ESCs have used isoprenaline and carbachol as the “standard” agonists to confirm that the physiological or electrophysiological properties of the derived cardiomyocytes resemble native tissue (Banach et al., 2003; He et al., 2003; Fu et al

• Partitioning of the dorsal telencephalon centers

  2018-10-29

  

  Partitioning of the dorsal telencephalon centers on the paired-box transcription factor Pax6. At the neural plate stage in the mouse, Pax6 expression is observed throughout the telencephalic anlagen, with later expression restricted primarily to the dorsal pallium neocortex domain (Pax6 expression h

• In this study we have employed mouse NSCs rather

  2018-10-29

  

  In this study, we have employed mouse NSCs rather than human NSCs to explore the effects of PA. In view of this, further study would be desirable to ascertain if comparable effects of PA occur in human NSCs. In addition, elevated FFA level is intimately associated with oxidative stress and high leve

• Both Brat and Mei P belong

  2018-10-29

  

  Both Brat and Mei-P26 belong to the Trim-NHL family of proteins, which have conserved functions in stem cell lineages from C. elegans to mouse (for review, see Wulczyn et al., 2010). Proteins within this family are potential E3 ubiquitin ligases and can act by either activating or antagonizing the m

• br Experimental Procedures br Acknowledgments

  2018-10-29

  

  Experimental Procedures Acknowledgments This work was supported by BONFOR/Gerok Scholarships O-137.0015 (to B.V.S.), Ruediger Foundation grants (to B.V.S.), State Scholarship Fund/Chinese Scholarship Council 2008627116 (to Z.L.), NIH – National Eye Institute 5R01EY022079-02 (to S.T.), and NYSD

• In our previous study we reported

  2018-10-26

  

  In our previous study, we reported a genetic diagnosis of a GT patient with two different mutations in the two ITGA2B alleles. Both mutations activated a same recessive intron splicing site and cause a 99-base deletion in IIb mRNA (Li et al., 2011). In the current study, we successfully established

• Cell adhesion molecules CAMs are

  2018-10-26

  

  Cell adhesion molecules (CAMs) are transmembrane proteins that are responsible for mediating adhesion of cells to other cells and/or the extracellular matrix via their extracellular domains, while their intracellular domain interacts with the cytoskeleton. Thus, CAMs provide a direct link between th

• In the present study we

  2018-10-26

  

  In the present study, we generated an Eva1a knockout (KO) mouse to study the physiological role of EVA1A in vivo. The analysis of Eva1a KO embryos and isolated NSCs revealed the function of EVA1A in self-renewal and neuronal differentiation of NSCs. Our study highlighted a previously unknown role of

• br Experimental Procedures br Author Contributions

  2018-10-26

  

  Experimental Procedures Author Contributions Acknowledgments We wish to thank Nicole Varain and Donna Colon for their excellent technical support assisting with the fetal sheep transplants. This work was supported by NIH, NHLBIR01HL097623, and the Intramural Pilot Program of Wake Forest Sch

• diazoxide ESCs were first discovered in

  2018-10-26

  

  ESCs were first discovered in 1981 independently by two groups (Martin, 1981; Evans and Kaufmann, 1981) and, while they were initially cultivated in medium containing physiological glucose (Glc) concentrations of 5.5 mM, descriptions of their routine cultivation in 25 mM Glc can be traced back to re

• br Results br Discussion Human HLCs derived from pluripotent

  2018-10-26

  

  Results Discussion Human HLCs derived from pluripotent stem apexbio are permissive to infection by hepatotropic viruses, including HCV and HBV. Interestingly, the SEC14L2 gene, an essential host factor for supporting the replication of wild-type, unadapted HCV genomes, was induced during the h

• Although we observed low overall rates of CNVs

  2018-10-26

  

  Although we observed low overall rates of CNVs, we observed five recurrently altered regions. Three of the intervals are quiescent, containing few (if any) regulatory elements and either low or unexpressed genes. However, one of these intervals (the chr16 interval) is recurrently aberrantly methylat

• The goal of this study was to understand how

  2018-10-26

  

  The goal of this study was to understand how synthetic hydrogels influence global biological function compared with standard 2D or 3D cell-culture formats. Vascular morphogenesis was chosen as a model biological system, and a bioinformatics approach was employed to provide genome-wide analysis for H

• br Introduction Retinoblastoma is the most

  2018-10-26

  

  Introduction Retinoblastoma is the most common primary intraocular pediatric cancer, with 95% of the cases diagnosed before 5 years of age (Kivela, 2009). Retinoblastoma is initiated by biallelic inactivation of the retinoblastoma 1 (RB1) gene. In heritable retinoblastoma, a primary germline muta

• br Experimental Commercial Luxeon Rebel ES LEDs produced

  2018-10-26

  

  Experimental Commercial Luxeon Rebel ES LEDs produced by Philips Lumileds have been the subject of our investigation. The area of the emitting chip was 1340 µm × 1340 µm. This device is known as the thin-film flip-chip InGaN/GaN multiple-quantum-well LED (TFFC LED) [3]. To provide efficient heat

14791 records 980/987 page Previous Next First page 上5页 976977978979980 下5页 Last page