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In addition we demonstrated that the combination of PCBP
2019-04-20
In addition, we demonstrated that the combination of PCBP2 siRNA and LY2109761 had a potent silencing effect on collagen expression (Fig. 8). Both HSC-T6 akt pathway and primary HSCs were used to evaluate the combinational treatment. LY2109761, a TGFβ receptor type I/II kinase inhibitor, has been us
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Understanding and defining these miRNA
2019-04-20
Understanding and defining these miRNA profiles helps to uncover the clinical usefulness of miRNAs. Numerous human clinical trials are currently evaluating miRNA therapeutics during various liver diseases, such as targeting miR-122 during chronic hepatitis C infection. Aside from therapeutics, the d
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Argentina adopta una posici n
2019-04-20
Argentina adopta una posición semejante RG7204 cost los anteriores países, Aborda el principio en la Ley 25675, incorpora un seguro como requisito para cubrir los posibles daños ambientales en las actividades riesgosas, específicamente señala el Artículo 22 de dicha ley. Asimismo, define el daño amb
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En el segundo caso la Espa a
2019-04-20
En el segundo caso, la España republicana se constituye como un espejo quebrado, aquello destruido, perdido y que es mejor olvidar para atender la historia urgente y presente del territorio latinoamericano, de muestra vale el ejemplo citado que refiere lysophospholipid receptor la importancia de cen
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Y es que en Estados Unidos el campo denominado Cultural
2019-04-20
Y es que, en Estados Unidos, el campo denominado Cultural Studies producía una gran cantidad de investigaciones sobre la región mediante categorías de análisis propias del llamado primer mundo. En su versión latinoamericana, los Estudios Culturales llegaron adenosine triphosphate consolidarse en los
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Second political regime does very little
2019-04-20
Second, political regime does very little to explain differences between countries. Rwanda, Congo (Brazzaville), and Tanzania have very similar child mortality rates (between 40 and 60 deaths per 1000 livebirths in 2014) to South Africa, Botswana, and Namibia despite the former countries being consi
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Previous studies have demonstrated localization of miR
2019-04-19
Previous studies have demonstrated localization of miR-21 staining in stromal tropisetron of OSCC associated with the tongue and mouth floor—this might be a useful prognostic predictor. We also observed miR-21 staining in the stromal cells of tumors. However, since multiple lines of evidence indica
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The patient received multiagent chemotherapy using cyclophos
2019-04-19
The patient received multiagent chemotherapy using cyclophosphamide, daunorubicin, vincristine, predonisolone and l-asparaginase, and high dose MTX/Ara-C, as well as the single-agent administration of nelarabine, hydroxyurea and tyrosine kinase inhibitors (TKIs) (imatinib and dasatinib). The convent
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br The paper in by Victoria
2019-04-19
The paper in by Victoria Fan and colleagues is important because it describes what several people close to the Global Fund to fight AIDS, Tuberculosis and Malaria already know: there is a problem with its disbursement mechanisms. Fan and colleagues correctly state that the Global Fund should “red
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br In its July editorial
2019-04-18
In its July editorial, drew attention to the ethical challenges posed by the Zika trk receptor outbreak. The Regional Program on Bioethics at the Pan American Health Organization (PAHO) arranged an ethics consultation, funded by the Wellcome Trust, to provide ethically sound guidance for the outbr
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Despite these recommendations diagnosing CIED infection coul
2019-04-18
Despite these recommendations, diagnosing CIED infection could be challenging. Early after implantation procedure it is important to differentiate CIED pocket infection from incisional erythema or superficial wound infection or stitch abscess. These cases usually resolve with local measures and some
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br Material and Methods br Results br Discussion Radiofreque
2019-04-18
Material and Methods Results Discussion Radiofrequency ablation has a long history of use. It has been used especially in the neurosurgical field [8,9]. Rosenthal described the first ablations in bone 20 years ago [5]. Technically the radiofrequency generator forms an electric current leadi
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br Discussion Primary lymphoma of bone is a rare disease
2019-04-18
Discussion Primary lymphoma of bone is a rare disease, first described by Oberling in 1928 and he labeled it as reticulum cell sarcoma of bone because of the presence of characteristic reticulin fibers within the lesion [5]. This work was followed by Parker and Jackson and later by Ivin and Bosto
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Long marginalised as a disorder confined to
2019-04-18
Long marginalised as a disorder confined to specific racial groups, sickle-cell disease is now assuming its rightful place as a major global public health problem. Most patients in the Americas, the Caribbean, and much of Europe have been of one racial group, which led to the common misconception th
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Many advocates assert that improved sanitation is a basic
2019-04-18
Many advocates assert that improved sanitation is a basic human right. The main justification for this assertion is that sanitation is essential for achievement of health and promotion of human dignity. If the justification for investment in sanitation is a right based on privacy and human dignity,
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