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br COTSget based Architectures This section describes how ou
2019-11-11
COTSget-based Architectures This section describes how our COTSget-based architectures are defined. We use a design inspired by MDE to build a Domain-Specific Language (DSL) of the architecture, as can be seen in the metamodel of Fig. 3. This metamodel defines the abstract syntax of our DSL and i
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br Acknowledgements br Introduction Water
2019-11-11
Acknowledgements Introduction Water and electrolytes constitute an integral part of all living things, and BADGE governing their movements play important roles in a wide variety of physiological and/or pathophysiological processes. Given the importance of channel proteins in cancer cell proli
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In the present study we examined whether the gene for
2019-11-11
In the present study we examined whether the gene for estrogen receptor alpha, Esr1, plays a role in the expression of maternal memory in female rats. The approach utilized a newly developed rat Esr1 knockout (KO) rat model (Rumi et al., 2014) to evaluate whether deletion of the Esr1 rp gift card a
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caspofungin br Oxidoreductase like MEM for
2019-11-11
Oxidoreductase-like MEM for prodrug activation Future outlook Although MEM-mediated prodrug activation has been performed by different MEMs and prodrugs, and their effectiveness have been proved in vivo, only a few types of MEMs or prodrugs have been explored in prodrug activation until now [2
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Introduction With an annual world production
2019-11-11
Introduction With an annual world production of around 750 million tons, wheat is grown on more agricultural area than any other food crop and is the main source of plant protein in human nutrition [1,2]. Wheat is composed of 8–15% protein, from which 85–90% is gluten [3]. The unique viscoelastic a
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The elastase induced injury model has been shown to produce
2019-11-11
The elastase-induced injury model has been shown to produce airspace enlargement, and increases in lung volume and compliance that are similar to those observed in human patients (Hantos et al., 2008, Hamakawa et al., 2011). Thus, this model, which has been used to study emphysema, should be adequat
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16,16-Dimethyl Prostaglandin E2 br Materials and methods br
2019-11-11
Materials and methods Results Discussion Studies have suggested that the Hh signaling pathway, which plays as an essential autocrine viability factor for MFBs [10], [11], is a potential therapeutic target for liver fibrosis. Previously reported works have proven the effectiveness of the Hh
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RS 127445 HCl australia Concerning family A GPCRs although i
2019-11-11
Concerning family A GPCRs, although it has been described that several receptors are able to operate as monomers (Arcemisbéhère et al., 2010; Bayburt et al., 2011; Chabre & le Maire, 2005; Ernst, Gramse, Kolbe, Hofmann, & Heck, 2007; Hanson et al., 2007; Kuszak et al., 2009; Whorton et al., 2007), e
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br Introduction Pattern separation is the ability
2019-11-11
Introduction Pattern separation is the ability to make distinct representations from highly overlapping information, a process which is important for memory encoding (Clelland et al., 2009). For correct pattern separation, old information needs to be retrieved and compared to new information. If
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Studies of LRRK tagged with
2019-11-08
Studies of LRRK2 tagged with green fluorescent protein revealed the presence of monomeric LRRK2 in the Epothilone B receptor of living cells, while LRRK2 oligomers were found in the proximity of the plasma membrane, suggesting that both oligomerization status and compartmentalization of LRRK2 defin
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In these studies the inflammatory
2019-11-08
In these studies, the inflammatory cytokine IL-8 was demonstrated as one of the responsible molecules induced by CysLTs via activating CysLT2 receptors. IL-8 is synthesized in and released from mononuclear cells, macrophages, fibroblasts and airway epithelial cells, and it promotes inflammation as a
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br P Y receptor structure br Pharmacology Several
2019-11-08
P2Y receptor structure Pharmacology Several subtype selective compounds have been developed in recent years (Jacobson and Müller, 2016; Rafehi and Müller, 2018). These compounds are helpful tools for analyzing the roles of P2Y receptor subtypes in physiology and pathophysiology. The present ar
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Dexamethasone DEX a potent synthetic glucocorticoid drug is
2019-11-08
Dexamethasone (DEX), a potent synthetic glucocorticoid drug, is effective for treatment of a range of inflammatory and autoimmune conditions as well as the reduction of side effects associated with chemotherapy. On the Czech Republic pharmaceutical market, DEX is incorporated into eighteen drugs use
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The X ray crystal structure of
2019-11-08
The X-ray crystal structure of palbociclib bound to CDK6 without a lenvatinib (PDB ID: 5L2I) is very similar to that of the CDK6-cyclin V structure (Fig. 7B). However, the drug binds to the αCout conformation of monomeric CDK6 while it binds to the αCin conformation of the CDK6-cyclin V complex. It
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The second constraint indicates that if the relationship bet
2019-11-08
The second constraint indicates that if the relationship between two components A and B is two-way, then there are at least two connectors, one with origin A and destination B, and another connector with origin B and destination A (OCL2 of Fig. 4). Therefore, at least one output port of the first co
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