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br RING dimerization RING type domains
2019-12-30
RING dimerization RING-type domains are found in many different structural contexts. While many exist as single-chain Z-IETD-FMK (Fig. 3A), a notable feature of RING-type E3s is their tendency to form homodimers and heterodimers (Fig. 3C–F). Homodimeric RING-type E3s include cIAP, RNF4, BIRC7 (s
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In plants SUMOylation has been shown to
2019-12-30
In plants, SUMOylation has been shown to modulate plant hormone signaling (Lois et al., 2003, Miura et al., 2009, Conti et al., 2014), root stem cell maintenance (Xu et al., 2013), and responses to abiotic and biotic stress (Lois, 2010). Many of the plant biological processes regulated by SUMOylatio
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br General Characteristics of the Type II Dehydrogenases Alt
2019-12-30
General Characteristics of the Type II Dehydrogenases Alternative NAD(P)H dehydrogenases conduct the reaction of the rotenone-insensitive oxidation of cytosolic and mitochondrial matrix NADH and/or NADPH (Fig. 1) (Melo et al., 2004, Rasmusson et al., 2004, Rasmusson et al., 2008). They catalyze t
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Estrogen related receptors ERRs are
2019-12-29
Estrogen-related receptors (ERRs) are orphan nuclear receptors and have three members including ERRα, ERRβ, and ERRγ (Yasumoto et al., 2007). Though they are termed as ERRs due to the sequence homology with estrogen receptors, they don’t need to bind estrogens to exert action. Generally, ERRs bind t
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br Inhibition of DHODH The
2019-12-29
Inhibition of DHODH The final products 7a–n were assessed for their DHODH inhibitory activity on rat liver mitochondrial/microsomal membranes. A procedure adapted from the literature was employed (see Experimental), in which oxidation of DHO to ORO is monitored by following the concomitant reduct
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Cholesterol homeostasis is maintained through a tight regula
2019-12-29
Cholesterol homeostasis is maintained through a tight regulation between endogenous de novo synthesis, dietary absorption, utilization and excretion of bile salts. The mst2 of cholesterol from the intestine constitutes the central part of cholesterol homeostasis in the body [41]. In particular, the
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One possible explanation for differences in the
2019-12-29
One possible explanation for differences in the binding ability of monomeric versus dimeric forms of DDR2 ECD to collagen could be that the monomeric form only binds to the primary GVMGFO site, whereas dimeric (and oligomeric) DDR2 ECD binds to additional sites on the collagen triple-helical molecul
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Introduction Collagen deposition is a common feature found i
2019-12-29
Introduction Collagen deposition is a common feature found in cancerous tissues and fibrotic organs/lesions. It is now well accepted that collagen deposition is not just a consequence of disease, but that it can also trigger a vicious cycle. Both chemical and physical signals elicited from collagen
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br Results br Discussion br Experimental Procedures br Ackno
2019-12-29
Results Discussion Experimental Procedures Acknowledgments In the preceding paper, we reported 3-amido-4-anilinoquinolines as highly selective inhibitors of CSF-1R kinase, along with our initial efforts to optimize the series. Examples from the 6,7-dimethoxyquinoline series were very p
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Table presents results for estimation of
2019-12-29
Table 4 presents results for estimation of Eq. (1) using ACTR and SUWE to compare the incidence of attempting the exam between programs. We find alumni are more likely to attempt the exam if they Thiola do not hold another professional certification, have worked for an accounting firm, have a highe
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Stable carbon and nitrogen isotope ratios in
2019-12-29
Stable carbon and nitrogen isotope ratios in bone collagen and carbon isotope ratios in bone apatite data were obtained by the means of the techniques described in supplementary data (SD1). For collagen, standard indicators have been used to assess its preservation, such as collagen yield, carbon an
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br Discussion EFTs are sarcomas with almost undifferentiated
2019-12-29
Discussion EFTs are sarcomas with almost undifferentiated histologic features, consequently their differentiation from other small, blue, round cell tumors may be difficult. Substantial intracellular VX-702 mg on PAS stain is a useful diagnostic feature. The addition of CD99 and FLI1 immunohisto
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ERRGO mice exhibited increased oxygen consumption
2019-12-29
ERRGO mice exhibited increased oxygen consumption, decreased RER, high running endurance, and resistance to diet-induced weight gain. These changes are physiological hallmarks of increased aerobic capacity in mice and are a direct consequence of engineering highly oxidative and vascularized muscle b
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br Conclusions The PQQ dependent CcPDH is the first
2019-12-28
Conclusions The PQQ-dependent CcPDH is the first PQQ-dependent enzyme identified in eukaryotes. The PQQ cofactor binds the enzyme with high affinity, reflected in a Kd of 1.1 nM, and the enzyme oxidizes 2KG, l-fucose, and rare sugars such as d-arabinose and l-galactose. The AA8 cytochrome b domai
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sphingosine sale The early serologic response of infants to
2019-12-28
The early serologic response of infants to infection with HIV-1 is obscured by the presence of transplacentally acquired maternal HIV antibody. However, the HIV sphingosine sale produced in vitro by peripheral blood from infants has been studied (Pollack et al., 1993) and it has been shown that neo
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