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Recent advances in microarray and next generation sequencing
2020-01-14
Recent advances in microarray [32] and next-generation sequencing [33] based technologies have led to tremendous increases in information about the molecular mechanisms that are responsible for malignant transformation of rare and poorly understood soft tissue sarcomas. However, data interpretation
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Neutrophils produce high amounts of ROS which
2020-01-14
Neutrophils produce high amounts of ROS, which act as antimicrobial agents, signaling molecules or initiators during PMA-induced NET formation. Of the intravenous anesthetics used in this study, propofol was the best at decreasing PMA-induced ROS levels (Fig. 3A and B). Our previous study also demon
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There may be an interplay of EP EP EP
2020-01-14
There may be an interplay of EP2, EP3, EP4 alone, or in combination, with EP1 for the onset of TCDD-induced neonatal hydronephrosis. EP2 and EP4 have been reported to increase AQP2 phosphorylation and membrane trafficking (Li et al., 2009; Olesen et al., 2011). The EP2 and EP4 mRNA concentrations we
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Emergence of antibiotic resistant strains of Mtb alongwith t
2020-01-14
Emergence of antibiotic resistant strains of Mtb alongwith the inefficacy of widely used Bacillus Calmette-Guerin (BCG) vaccine in adults are major challenges in the treatment and prevention of TB. Elucidation and characterization of new vaccine and drug candidates are therefore required in order to
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PRRSV is a single stranded positive sense enveloped
2020-01-14
PRRSV is a single-stranded, positive-sense enveloped RNA virus in the family Arteriviridae of the order Nidovirales (Meng et al., 1994, 1996). The PRRSV AM1241 synthesis is approximately 15 kb in length and contains eleven known open reading frames (ORFs) (Snijder et al., 2013). The 3′ end of the g
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In general cellular senescence is considered
2020-01-14
In general, cellular senescence is considered a programmed response to stress that can be activated by oxidative stress, irradiation or action of substances or drugs. These stressors cause DNA damage and, through the action of specific proteins (p53 and p21), lead to cell senescence (di Fagagna, 200
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Cyclo(RGDyK) receptor Till date several predictive models ha
2020-01-13
Till date, several predictive models have been developed by different research groups to speed up the process of library selection and drug optimization (Walters et al., 1999, Caldwell, 2000, Plewczynski et al., 2006, Wang and Ramnarayan, 1999, Pogorelcnik et al., 2015, Greenbaum et al., 2002, Sadow
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Keratin K has been identified as the first intermediate fila
2020-01-13
Keratin 8 (K8) has been identified as the first intermediate filament expressed during development in amphibians and mammals. In zebrafish, a type II cytokeratin 8 (zf-K8) cDNA has been cloned. zf-K8 gene was maternally inherited and expressed in all surface cells throughout the embryonic stages old
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Based on our studies presented above atipamezole can
2020-01-13
Based on our studies presented above, atipamezole can be used as a new in vitro and in vivo tool cytidine as a pan-CYP inhibitor for CYP mediated metabolism study. It carries many unique characteristics compared to ABT which is currently being widely used for this purpose. These new characteristics
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Here we describe a novel series of arylazoderivatives develo
2020-01-13
Here, we describe a novel series of arylazoderivatives developed from CAN508, one of the first known selective CDK9 inhibitors. We focused on modification of both ends of parental molecule, CAN508, in order to improve cytotoxicity and CDK activity. We therefore analyzed how changes in molecules will
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Previous work examining the link
2020-01-13
Previous work examining the link between the COMT gene and ISV is limited and has produced contradicting results. The Val allele was linked with higher ISV of RTs following target trials in a continuous performance task (Stefanis et al., 2005) and with higher ISV of RT and P3b latencies of unfamilia
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Although further experiments are needed to determine definit
2020-01-13
Although further experiments are needed to determine definitively whether D–ETB receptor heterodimers exist, for example, by using fluorescence resonance VU590 hydrochloride synthesis transfer analysis or co-immunoprecipitation of receptors, the results of the study by Zeng and colleagues appear to
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br Introduction Prostaglandins are important local mediators
2020-01-13
Introduction Prostaglandins are important local mediators in a host of reproductive processes including ovulation, fertilization, embryonic development, luteal regression, and parturition (Ushikubi et al., 2000). Prostaglandin E2 (PGE2) is among the more versatile prostanoids, and its effects app
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Among our patients with anti enolase drusen those with a
2020-01-13
Among our patients with anti-enolase drusen, those with a relatively short duration from the onset of visual symptoms to the first visit tended to have normal structure of photoreceptors with preserved visual function, despite the presence of drusen-related RPE abnormalities (Cases 1-3 and 8). In co
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Ample evidence has shown that ET
2020-01-13
Ample evidence has shown that ET-1 system plays a pivotal role in the development of cardiovascular anomalies and pharmacological inhibition of ETA prevents the development of cardiac hypertrophy [[37], [38], [39]]. Yanagisawa and coworkers, who first reported the cardiomyocyte-specific endothelin A
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