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In a larger study of patients with nondiabetic proteinuric
2020-09-03

In a larger study of 22 patients with nondiabetic proteinuric chronic kidney disease, BQ-123 produced significant natriuresis, resulting from increased renal blood flow. In addition, ETA antagonism reduced blood pressure and proteinuria, and, a new finding, decreased arterial stiffness. However, in
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br Results br Discussion br
2020-09-03

Results Discussion Materials and Methods Acknowledgment This work was funded by the Collaborative Research Centre (SFB) 807 of the German Research Foundation (DFG) and supported by the state of Hessen (Center for Biomolecular Magnetic Resonance) and the German Research Foundation (DO545/
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br Introduction In most of
2020-09-03

Introduction In most of the angiosperms, sexual reproduction requires a process called double fertilization where the specialized cell division called meiosis produces haploid gametes combine to form diploid (2n) embryo. In sennoside to this, apomixis, naturally occurs in at least 400 plant famil
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Our results indicate a deregulation of DNA methylation machi
2020-09-03

Our results indicate a deregulation of DNA methylation machinery during seed development in apomixis. Since DRM2 is targeted loci through an RNA-directed DNA methylation (RdDM) pathway involving 24-nt siRNAs (Stroud et al., 2014, Law and Jacobsen, 2010) and differentially expressed between apomict a
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br Material and methods br
2020-09-03

Material and methods Results and discussion Conclusions Acknowledgements S. De thanks DST, New Delhi for generous grant of the SERC Fast Track Scheme No. SR/FT/CS-057/2008. R. Kundu thanks the University of Kalyani for financial assistance. We are grateful to Prof. K. Bhattacharyya of IA
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Taking a pragmatic approach with a view to
2020-09-03

Taking a pragmatic approach with a view to complete the study and because chemotherapy regimens in NETs are not standardized, we do not impose a specific regimen in both arms. However, one regimen in each arm is recommended in order to reduce heterogeneity: the ALKY-based chemotherapy arm will recei
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In conclusion as illustrated in Fig G in
2020-09-03

In conclusion, as illustrated in Fig. 5G, in response to MNNG-induced DNA damage, PARP-1 appears to have dual roles in determining the cell fate in response to MNNG: PARP-1 activation is the cause of non-apoptotic cell death via ATP depletion and PARP-1 activation is able to elicit a self-protective
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The members in apple are similar
2020-09-03

The 8 members in apple are similar in number to the 7 in Arabidopsis and the 8 in rice, but fewer than the 10 found in mammalian species. GenBank numbers have also been reported for DGK homologues from tomato (AW035995), maize (AY106320), wheat (BT009326), a Populus cross (BU828590), grape (CB98113
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The preferences for source of FAs for
2020-09-03

The preferences for source of FAs for DGAT1 and DGAT2 are related to their membrane topologies, subcellular locations, interactions with other proteins or organelles (discussed in the former section), and their differential expression, substrate specificities, and enzyme kinetics. According to UniPr
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br Activatable bioorthogonal reactions reagents
2020-09-02

Activatable bioorthogonal reactions/reagents Cyclopropenes as bioorthogonal reagents for IEDDA substrates Cyclopropenes have become popular bioorthogonal reagents due to their small size, inertness to biological nucleophiles, ability to be genetically encoded (Yu et al., 2012), and participati
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SCF, murine recombinant protein mg br Material and Methods b
2020-09-02

Material and Methods Results and Discussion Conclusions Two chemical coupling agents, BTDE and CDI, were used to activate the free hydroxyl groups of plant cellulose powder and OPH from Flavobacterium ATCC 27551 immobilized on modified carriers by covalent linkages. The highest immobilizati
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The importance of EBI for B cell function was first
2020-09-02

The importance of EBI2 for B cell function was first suggested by the dramatic upregulation of this receptor in EBV-transformed kanamycin sulfate and further inferred from its regulation in activated and GC B cells (Birkenbach et al., 1993, Glynne et al., 2000, Shaffer et al., 2000). An involvement
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br A brief introduction to DUBs The reversal
2020-09-02

A brief introduction to DUBs The reversal of ubiquitin conjugation of targeted proteins relies on deubiquitinating Ferulenol (DUBs), which catalytically cleave single Ub or poly-ubiquitin chains from proteins. The human genome encodes approximately 100 potential DUBs which can be classified into
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The involvement of FOXO and STAT in DNA
2020-09-02

The involvement of FOXO3 and STAT5 in DNA-PKcs and Bisindolylmaleimide VIII acetate IV has not been reported before, and the search by the ECR browser (http://ecrbrowser.decode.org) revealed that 1kb of the 5′ promoter of DNA-PKcs possesses 4 STAT (−908bp to −901bp, −676bp to −656bp, −533bp to −526
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The ribosomal synthesis of D proteins
2020-09-02

The ribosomal synthesis of D-proteins is not currently feasible; the best effort undertaken so far was limited to the translational incorporation of two D-amino acids into the nascent protein chain by means of modified ribosomes (Dedkova et al., 2006). We therefore apply solid-phase peptide synthesi
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