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There is an opposite opinion indicating that EphB
2020-06-29
There is an opposite opinion indicating that EphB plays a role as cancer suppressor. Batlle et al. showed that loss of EphB expression represented a critical step in CRC progression, and CRCs that lacked EphB2 expression have been correlated with more advanced tumour stage, poor differentiation, and
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br Disclosure statement br Acknowledgements This
2020-06-29
Disclosure statement Acknowledgements This research was supported by grants from the National Institutes of Health, NS046400 and AG022971 (SD), and a fellowship from the Korea Research Foundation, KRF-2007-357-E00016 (YTK). The authors thank Dr. Barbara Crain for assistance with the immunologi
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Importantly we observed significantly the reduced myocardial
2020-06-29
Importantly, we observed significantly the reduced myocardial infarct size, the improved left ventricular function and the inhibited fibrosis after I/R with oral GA-BH4 supplementation before ischemia (Fig. 1, Fig. 2, Fig. 3). Usually, there is a view that the antioxidation induced by reducing agent
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br Acknowledgments We thank our colleagues who have
2020-06-29
Acknowledgments We thank our colleagues who have contributed to our understanding of the MTT and the structure and function of APC/C, and apologize to those whose work we were unable to cite here. We thank J. Rajan Prabu for making the movies showing APC/C conformational changes. Our work on APC/
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BMS 309403 receptor HCV has evolved mechanisms to
2020-06-29
HCV has evolved mechanisms to evade humoral immune responses including high functional flexibility and variability of immunogenic portions of its envelope proteins. The highest sequence variability occurs in the first 27 BMS 309403 receptor of the N-terminus of E2, which is referred to as the hyperv
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br Methods br Results br
2020-06-29
Methods Results Discussion Preclinical data indicate that nepicastat modulates sympathetic drive to the SM-164 with a mild pressor effect in various animal models of hypertension (Stanney et al., 1998). However in this clinical study, the doses of nepicastat employed did not significantly a
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For this reason we hypothesized that the
2020-06-28
For this reason we hypothesized that the DHFR gene could be a potential candidate in clefting. Our data, obtained using a family-based association approach, evidenced an association with borderline significance for the SNP rs1677693. The variant allele A at this marker seems to reduce the risk of C
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br MCADD review br Funding None br Introduction
2020-06-28
MCADD review Funding None. Introduction Bacteroides species are obligate anaerobes, Gram-negative, and non-spore-forming bacteria and 21 species of this genus are found particularly in the oral cavity and gastrointestinal tract in vertebrates [1,2]. B. fragilis is the most common Lomerizin
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br Materials and methods br Results and
2020-06-28
Materials and methods Results and discussion In the present work, we have applied two methodologies, CoMFA and CoMSIA to build 3D-QSAR models. There is no crystal structure available; therefore, an indirect method i.e., a ligand-based approach is the method of choice. The highly active molecul
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It is common for plants that are deficient
2020-06-28
It is common for plants that are deficient in P to invest in their roots in order to maximise P uptake from the soil. Here, plants grown in soil amended with OA had a higher root biomass:shoot azidothymidine ratio compared with plants in the INORG-P treatment. Additionally, greater allocation of C
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Although many of the genetic changes remain to be elucidated
2020-06-28
Although many of the genetic changes remain to be elucidated, there is evidence to support a difference in incidence and rate of rupture of cerebral aneurysms between men and women, and between pre- and postmenopausal women, suggesting that aneurysm formation may be affected by hormonal changes.18,
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Prostaglandin E receptor subtype EP is a transmembrane G cou
2020-06-28
Prostaglandin E receptor subtype 4 (EP4) is a transmembrane G-coupled protein receptor activated by prostaglandin E2 (PGE2). EP4 activation exerts anti-inflammatory effects in adipose tissue by dampening the levels of inflammatory chemokines [12]. In the mouse, EP4 deficiency aggravates fragmentatio
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4E1RCat br DDR receptor and MMP expression
2020-06-28
DDR2 receptor and MMP-13 expression Type II collagen protein in articular cartilage is highly stable structure as its half-life is 117 years [43]. The chondrocytes have limited ability to synthesis type II collagen protein in the matrix of mature articular cartilage once the collagen gets disrupt
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Oseltamivir br Conclusions br Acknowledgment br Introduction
2020-06-28
Conclusions Acknowledgment Introduction The role of cholesterol metabolism during multiple sclerosis (MS) is debated and the underlying physiopathology largely unknown. Dyslipidaemia is associated with worsening inflammatory activity and MS disease progression [1], [2], [3]. In the mouse mo
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Real time PCR as described previously with minor
2020-06-24
Real-time PCR, as described previously with minor modifications, was used to detect DNA . The PCR mixture (Qiagen) was as follows: 5mM MgCl2, 2.5μl of 10x PCR Buffer, 0.125μl of HotStarTaq DNA Polymerase, 0.25mM of each dNTP, 0.4μM of each primer and 0.1μM of FAMlabelled probe (‘5-aacaattggagggcaagg
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