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There are studies that evaluated the stability of CMV
2020-07-31
There are studies that evaluated the stability of CMV DNA over different periods of time. A study that evaluated stability of EDTA plasma samples stored over a 21-day period at 4 °C found no significant change in the viral loads or any trend of continued DNA degradation [9]. Another study did not fi
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Our results indicate that weakly or non interacting proteins
2020-07-30
Our results indicate that weakly or non-interacting proteins like TrkB may also contribute to delay in collagen fibrillogenesis. This can be explained using the model proposed by Parkinson et al. that fibrillogenesis can be modeled as a diffusion-limited aggregation of individual collagen molecules.
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In order to unravel patho physiological mechanisms involving
2020-07-30
In order to unravel (patho-)physiological mechanisms involving oxysterols, it is crucial to elucidate the underlying formation and degradation of oxysterols and to uncover their intracellular and tissue-specific site of metabolism. Whereas the formation of 7α25OHC involves two hydroxylation steps fr
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br Materials and methods br Results and discussion
2020-07-30
Materials and methods Results and discussion Conclusions BLAT analyses of the opossum and zebrafish genomes using the amino Bromosporine sequences reported for human and mouse DGAT1 and DGAT2-like protein subunits were undertaken to interrogate these genomes. Evidence is reported for an op
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Since hepatic steatosis and insulin resistance are
2020-07-30
Since hepatic steatosis and insulin resistance are often associated, other explanations must account for the relationship. One possibility is that hepatic steatosis, when present, is the result of insulin resistance, possibly because the insulin signaling pathways that drive fatty ritanserin biosyn
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br Acknowledgments Authors acknowledge financial support fro
2020-07-30
Acknowledgments Authors acknowledge financial support from the National Natural Science Foundation of China (31402274, 31172389), the Special Project of Marine Renewable Energy from the State Oceanic Administration (SHME2011SW02), China Postdoctoral Science Foundation (2014M551381) and Shanghai U
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Intriguingly our laboratory has shown that
2020-07-30
Intriguingly, our laboratory has shown that the I638F kinase domain mutant, unlike the L63V and G505 mutants, is incapable of receptor autophosphorylation and activation of its downstream effector SHP-2 when exposed to collagen stimulation. These data indicate that I638F is a loss of function mutati
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Cysteine proteases Cp are widely distributed among
2020-07-30
Cysteine proteases (Cp) are widely distributed among living organisms, found in both prokaryotes and eukaryotes (e.g. bacteria, parasites, plants, invertebrates and vertebrates) [13], [14]. The catalytic mechanism of these KN-93 Phosphate sale involves a cysteine group in the active site. Cp compri
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Rats were euthanized with Fatal Plus ml i p Vortech
2020-07-30
Rats were euthanized with Fatal Plus (0.5ml, i.p.; Vortech, Dearborn, MI, USA), brains were removed and fixed in 10% formalin. Brains were sectioned (60μm) on frozen, stained with cresyl violet, and analyzed under light microscope by two experimenters blind to treatment. Only data from rats with can
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br Materials and methods br Results br
2020-07-30
Materials and methods Results Discussion Consistent with previous reports (Barr et al., 2010, Vuong et al., 2010), the current study demonstrates that rats treated with amphetamine exhibit heightened anxiety states during withdrawal. Furthermore, icv. infusion of a CRF2 receptor antagonist
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We found that infants with severe SGA had a
2020-07-30
We found that infants with severe SGA had a higher incidence of abnormal CpG1 methylation in the placenta, though there was no significant difference in the average methylation of each CpG site among the three groups. It is noteworthy that not only hypomethylation but also hypermethylation were pred
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Activity levels were not increased in Dgat
2020-07-29
Activity levels were not increased in Dgat−/− mice fed the chow diet, even though their metabolic rates were higher. This result implies that at least one alternative mechanism mediates the increased 2768 australia expenditure of Dgat−/− mice in the basal, chow-fed state. Unanswered Questions Con
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br Materials and methods br Results
2020-07-29
Materials and methods Results Discussion DNA methylation is a heritable epigenetic modification that can contribute to HCC development (Mah and Lee, 2014). Aberrant DNA methylation of CDKL2 was first reported to be associated with HCC in a small sample of Taiwanese HCC tissues by methylatio
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br Introduction A major limiting factor in
2020-07-29
Introduction A major limiting factor in cancer chemotherapy is the toxicity of cytotoxic drugs to normal tissues. Attempts to circumvent this problem have led to the tumour targeting approach, and selonsertib to tumour-associated proteins have been used in the development of a number of targeted
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Enzyme and prodrug systems provide an attractive approach fo
2020-07-29
Enzyme and prodrug systems provide an attractive approach for cancer therapy [12], [13], [14]. Earlier studies tried to explore the possibility of utilising enzymes present within tumours to convert low toxicity prodrug to a cytotoxic agent but no unique tumour specific enzymes were found [15]. Thus
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