Archives
- 2018-07
- 2018-10
- 2018-11
- 2019-04
- 2019-05
- 2019-06
- 2019-07
- 2019-08
- 2019-09
- 2019-10
- 2019-11
- 2019-12
- 2020-01
- 2020-02
- 2020-03
- 2020-04
- 2020-05
- 2020-06
- 2020-07
- 2020-08
- 2020-09
- 2020-10
- 2020-11
- 2020-12
- 2021-01
- 2021-02
- 2021-03
- 2021-04
- 2021-05
- 2021-06
- 2021-07
- 2021-08
- 2021-09
- 2021-10
- 2021-11
- 2021-12
- 2022-01
- 2022-02
- 2022-03
- 2022-04
- 2022-05
- 2022-06
- 2022-07
- 2022-08
- 2022-09
- 2022-10
- 2022-11
- 2022-12
- 2023-01
- 2023-02
- 2023-03
- 2023-04
- 2023-05
- 2023-06
- 2023-08
- 2023-09
- 2023-10
- 2023-11
- 2023-12
- 2024-01
- 2024-02
- 2024-03
- 2024-04
- 2024-05
- 2024-06
- 2024-07
- 2024-08
- 2024-09
-
Over a century ago Dale compared the effects of
2020-08-04
Over a century ago, Dale [12] compared the effects of selected choline esters with the mushroom toxin, muscarine, and was the first to describe “muscarine-like” and “nicotine-like” actions. The relative potency of choline esters in isolated organ systems vs intact animals led him to posit that the “
-
The genetic basis of resistance to dieldrin
2020-08-04
The genetic basis of resistance to dieldrin has been described for several insect species as a mutation in the transmembrane domain II of the GABA-Cl or rdl (resistance to dieldrin) gene (ffrench-Constant et al., 2004; Bass et al., 2004; Du et al., 2005). A mutation in the GABA-Cl gene was found at
-
br Experimental br Results and discussion br Conclusions br
2020-08-04
Experimental Results and discussion Conclusions Acknowledgements The work was financially supported by the Natural Science Foundation of Liaoning Province of China (Grant No. 201602693). Introduction Hormone therapy (HT) is the treatment of choice for the management of bothersome men
-
Estrogens have a variety of positive effects
2020-08-04
Estrogens have a variety of positive effects on surrogate parameters for cardiovascular risk, although the Heart and Estrogen–Progestin Replacement Study (HERS) [70], [71] and WHI study [11] have not proven a positive effect in women with a previous event or in those with some progression of the dis
-
DPP also known as CD is a
2020-08-04
DPP-4 (also known as CD26) is a novel therapeutic target for T2DM. DPP-4 is a membrane-bound X-prolyl dipeptidyl peptidase, which involves the degradation of chemokines, such as stromal-cell derived factor 1 (SDF-1) and macrophage derived chemokine, and incretins, such as glucagon-like peptide 1 (GL
-
3\'-Azido-3\'-deoxythymidine β-D-glucuronide sodium
2020-08-03
Clinical testing for genomic copy-number aberrations and a connective-tissue gene panel of individuals 1 and 2 were normal (data not shown). Research exome sequencing, using both dominant and recessive models, was undertaken as described in the Supplemental Methods. We made a list of all variants sh
-
Although several examples of selective reduction of diazoest
2020-08-03
Although several examples of selective Novobiocin Sodium australia of α-diazoesters to α-hydrazonoesters have been described in the literature, reports on practical and general examples of such a process are scarce. In this context, there was a need to devise a mild and general method for the selec
-
ML-099 br Summary and discussion Our results suggest that
2020-08-03
Summary and discussion Our results suggest that, counter to Marques (2012), the creation of a successful accelerated program does not require a fundamental shift in the manner of pedagogy. This may help to overcome faculty objections to accelerated teaching. It is also important to note that our
-
Second we found a wide range of CMV
2020-08-03
Second, we found a wide range of CMV DNA loads measured in BAL fluid specimens from patients with pneumonia in whom CMV causality was unlikely or reasonably ruled out attending to clinical (including therapeutic response to nonanti-CMV drugs), radiographic, lung autopsy histopathology or BAL fluid G
-
br Results br Discussion LNX
2020-08-03
Results Discussion LNX1 was first identified as a binding partner of Numb and interacts with c-Src in a PDZ-dependent manner, triggering its ubiquitination [18]. Until recently, no structure-based mechanism had been established for the LNX family of proteins. Here, we identified the ubiquitin
-
Attempts to define the function
2020-08-03
Attempts to define the function of individual DGK domains have resulted in inconclusive results. ATP binding motifs corresponding to the glycine-rich loops found in protein kinases (GxGxxG consensus sequence; Hanks et al., 1988, Hemmer et al., 1997) were identified in the first C1 and catalytic doma
-
The third pillar is Cloud Computing The strengths
2020-08-01
The third pillar is Cloud Computing. The strengths of cloud computing for users and organizations have been widely described in the literature, e.g., [33] or [44]. The benefits identified include the use of Software-as-a-Service (SaaS) and specifically Models-as-a-Service (MaaS) as on-demand high-le
-
AD and dementia animal models have
2020-07-31
AD and dementia animal models have been used to confirm the neurovascular protective activity of curcumin and to illustrate the underlying mechanisms of its action (Bahramsoltani et al., 2017; Hoppe et al., 2013; Zhang et al., 2015). This natural AACOCF3 mg improved the Aβ induced-damage on synaptic
-
Microglia represent approximately of all glia found in
2020-07-31
Microglia represent approximately 5–10% of all glia found in the brain. Various proteases have been detected in the conditioned medium from microglial cell cultures including the metalloproteinase for Aβ40 degradation [34], the cysteine protease cathepsin B for neurodegeneration in the central nervo
-
The process of ubiquitination is a multi step
2020-07-31
The process of ubiquitination is a multi-step process ultimately leading to the covalent modification of a protein substrate with small molecule ubiquitin. There are three types of ubiquitination: 1) mono-ubiquitination in which single ubiquitin is attached to target 2) multi ubiquitination or poly-
14495 records 705/967 page Previous Next First page 上5页 701702703704705 下5页 Last page