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br Materials and methods br Results
2020-08-10
Materials and methods Results Discussion In the present study, as a trial to evaluate the marine ciliate E. crassus for further studies, its susceptibilities to B[a]P and β-NF were measured. Acute toxicity of B[a]P in aquatic organisms has been extensively studied, but not enough data is av
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We further examined our hypothesis that the activation of CR
2020-08-10
We further examined our hypothesis that the activation of CRF and CCK systems is responsible for the enhanced anxiety-like behavior induced by immobilization stress using two antagonists to block the expression of CRF1 and CCK2 receptors. It was found that CCK2 receptor antagonist CR2945 or CRF1 ant
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In general accurate results for the prediction of
2020-08-10
In general, accurate results for the prediction of the solubility in scCO2 + cosolvents using the CPA-EoS were verified. ALD values for each solute (Table 1) varied from 0.04 to 1.5. Few solutes, such as lauric acid, myristic acid, hydroquinone and salicylic acid, presented the highest ALD values. A
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The BDNF Val Met polymorphism is also associated
2020-08-10
The BDNF Val66Met polymorphism is also associated with decreased dendritic arborization and impaired long-term potentiation [25]. This is particularly important for the hippocampus, and healthy individuals with a BDNF Val66Met allele have decreased hippocampal volumes [30]. Hippocampal atrophy is co
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br Conclusions In the present study decreased AChE and
2020-08-10
Conclusions In the present study, decreased AChE and increased BuChE and BeChE activities were observed in greenhouse workers relative to control subjects; however, these changes cannot be related to OP exposure but likely to pesticide-induced oxidative stress or a mild inflammatory state. The in
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The highest concentrations from several tens to often hundre
2020-08-10
The highest concentrations (from several tens to often hundreds or thousands ng/L) are reported in animal farm flush water, and associated runoffs and lagoons in China and in the U.S. Lower concentrations are reported in WWTP influents and effluents. In WWTP influent waters DRO, LNG, NET and PRG hav
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Compression The L vertebral body
2020-08-10
Compression: The L4 vertebral body was tested in compression with loads applied along the craniocaudal axis using an Instron 8800 device at a rate of 3mm/min. Load displacement data were captured using Bluehill software. The ultimate load, yield load, stiffness, ultimate stress, yield stress and You
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br Materials and methods br Results
2020-08-10
Materials and methods Results Discussion Here we show expression of the EP1 receptor in the hippocampus of mice and the functional influence of the EP1 receptor on kainic Lapatinib australia induced seizures. Mice lacking a functional EP1 receptor gene displayed a lower tendency to enter st
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An Ubl modification requires several
2020-08-10
An Ubl modification requires several steps that are catalyzed by three enzymes, referred to as E1 (activating enzyme), E2 (conjugation enzyme), and E3 (ligase). The SUMO E1 is a heterodimer of SAE1 and Uba2 (also known as SAE2). In brief, an Ubl is first activated by E1 through ATP hydrolysis and fo
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1 98 mg In principle in vitro techniques
2020-08-10
In principle, in vitro techniques for assessing enzyme induction might include the use of cultured hepatocytes, precision-cut liver slices, immortalized 1 98 mg lines (such as those derived from hepatomas) and reporter gene constructs (where appropriate cells are transfected with recombinant DNA enc
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We have previously disclosed the discovery of
2020-08-08
We have previously disclosed the discovery of a 7-azaindole-3-acetic 25-hydroxyvitamin d3 CRTh2 antagonist chemotype 1 from HTS and its subsequent optimization to give 2 as a potent and orally bioavailable inhibitor of eosinophil shape change (SC) in human whole blood. Subsequent to disclosure of t
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In the course of this study
2020-08-07
In the course of this study, K+PFOS did not appear to have any effect on the thyroid parameters evaluated (H&E histology, follicular epithelial cell proliferation, and follicular epithelial apoptosis). This is an interesting observation considering the fact that treatment with K+PFOS resulted in act
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br Basic characteristics of ENO Alpha enolase also known as
2020-08-06
Basic characteristics of ENO1 Alpha-enolase, also known as 2-phospho-D-glycerate hydrolase, is a metalloenzyme that catalyzes the conversion of 2-phosphoglyceric Streptomycin sulfate to phosphoenolpyruvic acid in the glycolytic pathway. Petrak et al. (2008) statistically analyzed the frequency o
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Mammalian DGKs comprise a large protein family that
2020-08-06
Mammalian DGKs comprise a large protein family that consists of ten isozymes, which are classified into five subgroups based on the presence of a variety of regulatory domains [[1], [2], [3], [4]]. Type I DGKs, which consist of α, β and γ-isozymes, contain two sets of Ca2+-binding EF-hand motifs (EF
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Indeed some cancers may even
2020-08-06
Indeed, some cancers may even be defined by dysregulated cyclin and thus CDK activity: mantle cell lymphoma, an uncommon lymphoma of mature B cells, is defined by the presence of overexpressed cyclin D1, usually as a result of a translocation between chromosomes 11 and 14 with the net result that cy
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