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APJ receptor expression is altered in various cardiovascular
2024-06-21
APJ receptor expression is altered in various cardiovascular diseases, and both increases as well as decreases in APJ receptor expression have been reported. A decrease in mRNA and protein levels of APJ receptors was observed in patients with ischemic heart disease or idiopathic dilated cardiomyopat
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Angiogenesis is a process of formation of new
2024-06-21
Angiogenesis is a process of formation of new vessels from arterial vascularization created by endothelial cells. It is essential for the continuous growth of the tumor because it supplies the tumor with nutrients and oxygen, and eliminates cellular waste, which can be toxic to cancer cells [8]. Inf
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br Combination Effective RAS inhibition which is important f
2024-06-21
Combination Effective RAS inhibition, which is important for Deferoxamine mesylate sale control as well for the management of associated illnesses, can be produced through proper selection and dose maintenance and also by the combination with other antihypertensive agents along with continuous m
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A number of studies indicate
2024-06-21
A number of studies indicate the involvement of the classical AR or a splice variant that translocate to the membrane, via a palmitoylation mechanism, similar to ERα (Acconcia et al., 2005, Acconcia et al., 2004, Acconcia et al., 2003), since AR equally contains the required nine amino DPQ palmitoy
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br Applications of ATN in clinical trials
2024-06-20
Applications of ATN in clinical trials In pivotal trials, the use of biomarkers will also have to be considered in the context of regulatory risk and scrutiny. Although an important intended application of the framework is in research studies, its use will undoubtedly impact clinical development
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Interaction between AhR and ligands leads to AhR transformat
2024-06-20
Interaction between AhR and ligands leads to AhR transformation (Fig. 1), characterized by a rapid receptor nuclear translocation and the formation of AhR/Arnt complex and the release of the chaperone proteins. Following AhR transformation, the AhR/Arnt complex binds to its cognate DNA consensus seq
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ttp stock The enzyme plays an important role
2024-06-20
The enzyme plays an important role in the purine metabolism of this parasite. Like other parasitic protozoa, T. gondii is incapable of de novo purine biosynthesis and depends totally on preformed purines salvaged from the host ttp stock for its purine requirements and survival (Perrotto et al., 197
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In model plant Arabidopsis there are myosin XI isoforms XI
2024-06-20
In model plant Arabidopsis, there are 13 myosin XI isoforms (XI-1, XI-2, XI-A, XI-B, XI-C, XI-D, XI-E, XI-F, XI-G, XI-H, XI-I, XI-J, and XI-K) and 4 myosin VIII isoforms (ATM1, ATM2, VIII-A, VIII-B) [9,13]. Arabidopsis myosin XIs have the common domain composition: a motor domain that interacts with
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br Funding br Introduction l Dihydroxyphenylalanine l DOPA
2024-06-20
Funding Introduction l-3,4-Dihydroxyphenylalanine (l-DOPA) is the gold-standard treatment for the motor symptoms of Parkinson's disease (PD); however, its chronic use induces severe motor complications that eventually limit its long-term efficacy (Bastide et al., 2015). The most disabling side
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Because of its role in tumor growth proliferation and
2024-06-20
Because of its role in tumor growth, proliferation and metastasis, Axl is considered a therapeutic target. Several Axl inhibitors, including low-molecular-weight agents and antibodies, have been reported. Axl inhibition, using low-molecular-weight inhibitors or shRNA knockdown, resulted in reduced t
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br Conflict of interest br Acknowledgments This
2024-06-20
Conflict of interest Acknowledgments This work was been partially supported by the following grants: C.I.S.I.A. project (Innovazione e Sviluppo del Mezzogiorno—Conoscenze Integrate per Sostenibilità ed Innovazione del Made in Italy Agroalimentare—Legge 191/2009) from the Italian Ministry of Ec
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However most of these SBVS
2024-06-20
However, most of these SBVS studies were focused on the target(s) for which crystal structures were available or have a similar template in PDB for comparative modeling. Besides, these were limited to SBVS only which relies on the rigid binding pocket, therefore, it may result in high false positive
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br Apelin Discovered in apelin was initially identified as t
2024-06-19
Apelin Discovered in 1998, apelin was initially identified as the sole endogenous ligand for the APJ receptor (Tatemoto et al., 1998). Apelin-77 (pre-pro-apelin) is the precursor for various pharmacologically active apelin isoforms (e.g. apelin-12, -13, -17 and 36), and it shares 75–95% sequence
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Coincident with APJ receptor several cell types in
2024-06-19
Coincident with APJ receptor, several cell types in the body can synthesize apelin protein. For example, the highest apelin concentrations in the body have been found in the rat central nervous system, pituitary gland, lungs, cardiac muscle, gastrointestinal tract and mammary glands, with lower valu
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br Materials and methods br Results br Discussion
2024-06-19
Materials and methods Results Discussion Pulmonary fibrosis is a progressive and chronic lung disease and its typical features include 398 proliferation, epithelial injury, chronic interstitial inflammation, increased extracellular matrix (ECM) production, and collapse of alveoli, all of w
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