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Previous studies from our laboratory in CD
2021-04-27
Previous studies from our laboratory in CD1 mice using the incisional postoperative pain model have shown that the incision induces significant mechanical postoperative hyperalgesia lasting between 7 and 10days, with peak effect between 4h-2days (Cabañero et al., 2009a, Cabañero et al., 2009b, Campi
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The enzyme cyclooxygenase COX or prostaglandin endoperoxide
2021-04-27
The enzyme cyclooxygenase (COX) or prostaglandin endoperoxide H synthase (PGHS) is the key enzyme in the conversion of arachidonic Lurasidone HCl receptor (AA) into prostaglandins (PGs) [1]. In 1991, researchers found that there were two isoforms of this enzyme called COX-1 and COX-2 with independe
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Previous studies have documented that
2021-04-27
Previous studies have documented that SCFAs may elicit effects on lipid metabolism via de novo synthesis and transport. Acetate is not only used as an energy source, but is also constituted as a substrate for the cholesterol synthesis in the liver through acetyl-CoA, thus affecting plasma cholestero
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br Results Patient disease and treatment characteristics
2021-04-27
Results Patient, disease, and treatment characteristics of the study cohort are described in Table 1. All patients were stage IIIA with pathologically documented N2 disease per AJCC 7th edition. EP4 nuclear staining 0–1 versus 2+ was significantly associated with overall survival (OS) (44.3 vs.
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In conclusion substrate enabled effective detection of L ala
2021-04-27
In conclusion, substrate enabled effective detection of L-alanylaminopeptidase activity in all Gram-negative bacteria tested here. The chromogenic substrate showed high sensitivity at a relatively low concentration (50 mgL), with no diffusion of the coloured chelate into the surrounding agar. Lack
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BCECF-AM In view of the hypotensive effect of
2021-04-27
In view of the hypotensive effect of endothelial-specific overexpression of eNOS [17], [19], [28] we correlated skeletal muscle eNOS expression with sBP including data on colony 5 of eNOS-Tg [17] which was used to generate eNOS-Tg/KO (Fig. 4D). We found a highly significant one phase exponential dec
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br Acknowledgments br Introduction Inflammation
2021-04-27
Acknowledgments Introduction Inflammation is the protective reaction of the body to infection, injury, or irritation with the aim to remove harmful stimuli such as pathogens, damaged cells, or allergic irritants and to initiate the healing process. Inflammatory abnormalities play a crucial rol
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Main Text Post translational modifications by
2021-04-27
Main Text Post-translational modifications by ubiquitin (Ub) and ubiquitin-like proteins (Ubl) regulate a diverse array of cellular and physiological processes including protein degradation, localization, and activation. While ubiquitination has primary responsibility for targeting substrates for p
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GLP signaling mediates important renal functions as suggeste
2021-04-26
GLP-1 signaling mediates important renal functions [101], as suggested by the expression of both DPP-4 and GLP-1R in the kidney of several species, including humans [102]. However, controversial data exists on the specific expression pattern of these proteins, based on the specificity and sensitivit
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br Conflicts of interest br Introduction
2021-04-26
Conflicts of interest Introduction Arylamine N-acetyltransferase 1 (NAT1, EC 2.3.1.5) is a cytosolic enzyme that catalyses the acetylation of small molecule arylamines, hydrazines and sulphonamides (Hein, 2002). Found in most Anisomycin in the body, NAT1 expression is regulated at the transcri
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An important strength of our study is the use
2021-04-26
An important strength of our study is the use of an elastic net regression model to select the variable and construct the model, which performed ideally in terms of both predictive accuracy and sparsity for the high-dimensional datasets [16]. As a result, the apparent predictive effect of multiple c
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Introduction Cytochrome P CYP A
2021-04-26
Introduction Cytochrome P450 (CYP)3A is the most important enzyme involved in the metabolism of 30–40% of currently prescribed drugs [1]. The Camptothecin level and activity of CYP3A show large intra- and inter-individual variability, which contributes to unpredictable drug response and toxicity.
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KB-R7943 mesylate Some studies have demonstrated that BMSCs
2021-04-26
Some studies have demonstrated that BMSCs can provide several trophic and growth factors that play important roles in cell survival, angiogenesis, and BMSC differentiation, but not cell replacement (Peled et al., 1999, Shen et al., 2007, Ji et al., 2004). This paracrine effect of BMSCs is a potentia
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br Financial Support We would like to acknowledge financial
2021-04-26
Financial Support We would like to acknowledge financial support by the National Natural Science Foundation of China (grant numbers 81672778 and 81372165) and Natural Science Foundation of Beijing Municipality (grant number 5142009). Acknowledgements Introduction The process of spermatogen
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br Introduction Proteins therapeutic can be defined as prote
2021-04-26
Introduction Proteins therapeutic can be defined as proteins that are either naturally produced in the body or created in the laboratory and introduced into the patient with the aim of improving or curing a pathological condition. They are usually acquired from either microbial parp inhibitor or
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