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These cognitive deficits may suggest that cognitive therapy
2021-05-08
These cognitive deficits may suggest that cognitive therapy and pharmacotherapy for gambling behavior may ultimately wish to consider genotyping as a means of better targeting treatment approaches. If core cognitive deficits are shown consistently in certain subgroups of gamblers based on genotype,
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During the past decades HT had been
2021-05-08
During the past decades HT had been widely prescribed with the expectation of both osteoporosis and cardiovascular disease prevention. The results of the Women's Health Initiative (WHI) trial, however, indicated that long-term HT use is associated with a small but significant increase of cardiovascu
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br Introduction Cell transplantation therapies
2021-05-08
Introduction Cell transplantation therapies using embryonic stem cell (ESC) and induced pluripotent stem cell (iPSC)-derived retinal tissue (ESC/iPSC retina) or Docetaxel synthesis have emerged as therapeutic options for retinal degeneration following recent breakthroughs. A number of groups have
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br Substrate characterization of candidate peptide reporters
2021-05-08
Substrate characterization of candidate peptide reporters in a library Measurement of resistance to intracellular proteases Use of capillary zone electrophoresis for assay readout Selection of lead peptide from small library screen Characterization of final reporter Additional modif
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The isomeric phenyloxazole not only exhibited increased pote
2021-05-08
The isomeric 5-phenyloxazole not only exhibited increased potency against NEP, but also a decreased ACE inhibition thus providing encouraging selectivity. Changing the P1 group from an -propyl to a more polar methoxyethyl at the left hand Wang Resin synthesis (as seen in compound pairs – and –) decr
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br Results br Discussion Taking advantage of
2021-05-08
Results Discussion Taking advantage of the highly specific protein–protein interactions among cognate Bleomycin Sulfate that mediate SUMO conjugation to substrates, we have developed a novel strategy for achieving inhibition of SUMO conjugation in vivo based on disruption of SUMO E1–E2 intera
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Many investigators participated in the studies on the
2021-05-08
Many investigators participated in the studies on the regulation of the buy adenosine triphosphate and experiments indicated that the process was conserved across many eukaryotic species including humans [127]. Because cancer cells exhibit dysregulated cell division along with the presence of abnor
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br Conclusions br Source of
2021-05-07
Conclusions Source of financial support or funding This investigation was supported by the University of Utah Study Design and Biostatistics Center, with funding in part from the National Center for Research Resources and the National Center for Advancing Translational Sciences, National Insti
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Recent studies have shown that
2021-05-07
Recent studies have shown that some CLC genes participate in plant salt tolerance and have speculated that they function by mediating Cl− transport across the tonoplast. For instance, AtCLCc, a vacuolar anion transporter, is shown to be involved in the regulation of stomatal movement and to contribu
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In this study we also conducted an analysis comparing
2021-05-07
In this study, we also conducted an analysis comparing the expression profiling of Hh genes among the sarcomas investigated. In these tumors, the IHH gene showed a higher expression level than PTCH1 gene in RMS and SS samples (paristocort in human RMS cell lines as well as mouse NIH-3T3 fibroblasts
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Compound was prepared from chloroindole by acylation
2021-05-07
Compound was prepared from 6-chloroindole () () by acylation, to give , and subsequent reduction to give . The thiazole was then installed using conditions developed by Buchwald and co-workers to give . Hydrolysis of the ester yielded the thiazole mk2206 derivative (). Derivatives and were prepared
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The Penicillium strain used in this
2021-05-07
The Penicillium strain used in this work was isolated from Atlantic forest soil and previously screened as lipase producer (Tauk-Tornisielo et al., 2005). The immobilization was previously evaluated using hydrophobic supports, i.e. agarose based butyl-(But), phenyl-(Phe) and octyl-Sepharose (Oct), a
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To study the role of
2021-05-07
To study the role of DNA–PK in the response to replication arrest, we used the DNA replication inhibitor aphidicolin (APH). APH, a mycotoxin isolated from Cephalosporium aphidicola, inhibits DNA replication by interacting with the replicating DNA polymerase α (pol α). APH specifically inhibits the a
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The repair pathway of DNA DSBs through HR
2021-05-07
The repair pathway of DNA-DSBs through HR and the role of BRCA1 in repair kinetics by HR is also an important factor to unravel the radiation sensitization of novel small molecule inhibitors. The involvement of the breast cancer susceptibility gene 1 (BRCA1) in tumorigenesis and its role in facilita
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Functionally all members of the IL family
2021-05-06
Functionally, all members of the IL-12 family have been annotated along major inflammatory signaling axes but their roles have often weighed on opposing sides of the immunological balance. For instance, IL-12 and IL-23 are classified as pro-inflammatory cytokines [10] as opposed to the rather protec
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