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The first hint that GLP might not be
2021-06-07
The first hint that GLP-1 might not be completely stable came from a meeting abstract in 1992, reporting that GLP-1 could be degraded in plasma incubations [16], although the enzyme(s) involved was not identified. A year later, Mentlein and colleagues [17], in a search for peptide substrates of the
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CellProfiler and OpenComet are two
2021-06-07
CellProfiler and OpenComet are two open source software available in internet to analyse silver stained comet assay images. With CellProfiler [19], Gonzalez et al. [18] modified the pipeline provided in the website by adding a background subtraction module and two filtering modules to quantify DNA d
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The involvement of FOXO and STAT in
2021-06-07
The involvement of FOXO3 and STAT5 in DNA-PKcs and 1 646 IV has not been reported before, and the search by the ECR browser (http://ecrbrowser.decode.org) revealed that 1kb of the 5′ promoter of DNA-PKcs possesses 4 STAT (−908bp to −901bp, −676bp to −656bp, −533bp to −526bp and −66bp to −59bp) and
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Indeed a significant difference was observed for the binding
2021-06-07
Indeed, a significant difference was observed for the binding of glycated α-synuclein. Thus, g-α-synuclein bound to other part of GAPDH in 4 of 10 simulations (Fig. 2F, brown, yellow and dark-green chains, and Fig. 2G, brown chain). This additional binding site is located on the interface between O
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These data raised from human tissues suggested a potential l
2021-06-07
These data raised from human tissues suggested a potential link between TGF-β1 signaling and linear invadosome machinery that may explain TGF-β involvement in HCC progression and invasion. Using HCC cultured cells, we confirmed that TGF-β1 stimulation increases the production and secretion of collag
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TH287 synthesis The mitogen activated protein kinase MAPK fa
2021-06-07
The mitogen-activated protein kinase (MAPK) family, which consists of extracellular signal-regulated protein kinase 1/2 (ERK1/2), p38 MAPK, and c-Jun N-terminal kinase (JNK), is involved in the development of NP (Hung et al., 2012, Ji et al., 2009). Recently, Zhuang et al. (2005) demonstrated that t
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Carbonization and decarbonation are two different
2021-06-07
Carbonization and decarbonation are two different phases in the decomposition of rice husk. Silica in RHA melts around 1440°C [5]. Burning of rice husk at temperature lower than 800°C produces reactive amorphous silica which contains approximately 90% silica, whereas above this temperature some crys
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TgTCEA from petals TgTCEA and TgTCEB from
2021-06-05
TgTCEA from petals (TgTCEA1) and TgTCEB from pollen grains (TgTCEB1) were used throughout the study. The recombinant enzymes were expressed in , and purified as the His-tag-free forms as described previously., Enzyme reactions were performed at 4 mM substrates under the same conditions as described
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Given its high frequency it is not surprising that different
2021-06-05
Given its high frequency, it is not surprising that different strategies have been developed to restore the sensitivity of EGFR T790M-mutant Rifapentine to EGFR inhibition. To date, several different strategies have been evaluated in both preclinical and clinical models, but only few have been prove
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Similar to EGFR another receptor tyrosine kinase
2021-06-05
Similar to EGFR, another receptor tyrosine kinase (RTK), fibroblast growth factor receptor 4 (FGFR4), is gaining attention in the lung cancer setting. The protein expression of this receptor has been recently associated with a negative impact on lung cancer prognosis, supporting the idea that FGFR4
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dna-pk inhibitor Taken together these assays demonstrate tha
2021-06-05
Taken together, these assays demonstrate that SUMOD positioning is essential for all E3 ligases but dispensable for E2 and S*E2 sumoylation reactions. Thus, we propose SUMOD positioning as a key criterion to describe the enzymatic function of SUMO E3 ligases that distinguishes them from other enhanc
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The data from the Sur lab
2021-06-05
The data from the Sur lab have showed DNA-PK is involved in metabolic gene regulation in response to insulin. DNA-PK regulates fatty MMAF mg synthesis by modulating the protein expression of fatty acid synthase (FAS) in a feeding-dependent manner. DNA-PK induces the activation of Upstream Stimulato
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APY29 br Development of the double strand break repair model
2021-06-05
Development of the double strand break repair model for meiotic recombination Meiotic recombination was first described by Frans Alfons Janssens using APY29 in the salamander Batracoseps attenuatus in 1909 [21] and then further elaborated at the genetic level in Drosophila by Thomas H. Morgan [2
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Experimental studies offer a means of developing an empirica
2021-06-05
Experimental studies offer a means of developing an empirical basis for the development of forensic protocols in the investigations of specific crime types [12]. Such an evidence Regorafenib hydrochloride for ICST cases will help enable the identification of situations when there is likely to be re
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A third aim of our investigation
2021-06-05
A third aim of our investigation was to evaluate the impact of the methylation profile of p15, p16, p53, and DAPK, individually or combined, on progression-free and overall survival. We did not find any statistically significant difference in progression-free survival and overall survival in MM case
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