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br Tissue Specific Roles for HIF PHD
2021-09-07
Tissue-Specific Roles for HIF/PHD Isoforms Hypoxia signaling pathways are active in almost all mammalian cells, including immune Taurine and tissues such as the epithelium and endothelium. This is of crucial importance when considering the influence of environmental hypoxia in inflammatory condi
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More recently Vismodegib was administered
2021-09-07
More recently, Vismodegib was administered in combination with Gemcitabine in a pilot clinical trial that enrolled 23 patients affected by metastatic pancreatic adenocarcinoma. This type of malignancy is the most frequent form of pancreas cancer and is ranked in fourth place for cancer mortality in
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br Authors contribution br Funding sources This
2021-09-07
Authors' contribution Funding sources This study was supported by CDC intramural funding. Publication costs are funded by an internal program of CDC. MAT was supported by funds from the Association of Public Health Laboratories and CDC (APHL–CDC) Bioinformatics Fellowship Program. Competing
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Here we used Drosophila and mouse
2021-09-07
Here, we used Drosophila and mouse models to address the biological function of RALs in the adult intestine. Our results demonstrate a conserved in vivo role for RALs in ISC function during tissue homeostasis and regeneration. ISCs lacking RALs were at a disadvantage compared to wild-type neighbors.
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Cerulenin In the pathogenesis of insulin resistance
2021-09-07
In the pathogenesis of insulin resistance, chronic activation of inflammatory pathways plays an important role, and the macrophage/adipocyte inter-communication provides a key mechanism underlying the common disease states of decreased insulin sensitivity [10]. This involves the migration of macroph
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We also noticed that acetic acid by itself used
2021-09-07
We also noticed that acetic acid by itself (used to induce pain) increased spinal cord levels of KYNA (see Fig. 5). The most rational explanation of this finding is based on the possibility that acetic acid and KYNA share the same transport systems and the finding is therefore not surprising. Altho
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br Results and discussion br
2021-09-07
Results and discussion Conclusions Introduction There is no effective treatment for HIV-associated neurocognitive disorder (HAND) which affects about half of the over 36 million people infected (Saylor et al., 2016). HIV can remain in the PRIMA-1 mg during combination antiretroviral therap
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Overall our results indicated the involvement of GABAAR
2021-09-07
Overall, our results indicated the involvement of GABAAR in controlling GnRH/LH release through mechanism which included GABA action on molecular processes leading to GnRH biosynthesis. This is consistent with previous in vivo [14,54] and in vitro [55] studies in ewes suggesting that GABA inhibits G
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To further investigate the molecular
2021-09-07
To further investigate the molecular mechanisms that underlie glycine's β-cell protective effects through its antioxidative activity in diabetes, we used a H2O2/high glucose-induced apoptosis cell model. Similar effects on ROS generation of high glucose and H2O2 support the in vivo results, suggesti
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The aims of the present study were to
2021-09-07
The aims of the present study were to further investigate the localisation of glycine and GABAA receptors on individual neurons and how closely these two receptor types were associated with each other by carrying out double immunofluorescent labelling and imaged using confocal laser scanning microsc
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To confirm that these were bona fide interactions we investi
2021-09-07
To confirm that these were bona fide interactions, we investigated whether the potassium channel subunits or Tmem263 formed complexes with GLT-1 or DAT after immunoprecipitation. Lysates of HEK-293 cells previously cotransfected with HA-GLT-1 or HA-DAT, and either YFP-Kv7.3, YFP-Kv7.2 or YFP-Kv7.5 w
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Next we investigated the transfer of peptides and proteins
2021-09-06
Next, we investigated the transfer of peptides and proteins between contacting cells by nano-LC-MS/MS analysis using the fractions corresponding to molecules higher than 3 kDa. The MS data analysis revealed the direct transfer of several labelled peptides between receivers and donors. Labelled pepti
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br Conclusion In summary a series of novel GPR
2021-09-06
Conclusion In summary, a series of novel GPR40 agonists bearing phenylpropiolic gpcr signaling pathway motif with favorable metabolic stability were prepared and evaluated for their activities as GPR40 agonists. Among them, compound 9 was identified as a structurally distinct GPR40 agonist posse
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Factor Xa FXa has emerged as
2021-09-06
Factor Xa (FXa) has emerged as a particularly promising target for the development of effective anticoagulant drugs because FXa acts at the convergence point of the extrinsic and intrinsic coagulation pathways. It efficiently catalyzes the conversion of prothrombin to thrombin with one molecule of F
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Here we examined Meckel s cartilage
2021-09-06
Here, we examined Meckel's cartilage of mice where Setdb1 was knocked out only in neural crest derived Z-VDVAD-FMK with the purpose of investigating the roles of Setdb1 in Meckel's cartilage, a supportive tissue for mandible formation. We observed enlarged Meckel's cartilage that was a result of in
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