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The normal function of the FBPase enzyme is to
2021-11-09
The normal function of the FBPase enzyme is to catalyze the hydrolysis of F1,6BP to F6P. This activity is induced by diabetes and starvation and is increased in diabetic rats. The level of FBPase can be normalized by insulin, however, similar information is not available from diabetic patients. FBPa
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br RESULTS br DISCUSSION In this study
2021-11-09
RESULTS DISCUSSION In this study, we found impaired apoptosis in the peripheral blood of RA patients when compared with peripheral blood from normal controls. Our previous studies have shown that the number of CD4 + T ivacaftor increased while regulatory T (Treg) cells diminished in the perip
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The primary or in transit site
2021-11-09
The primary or in-transit site of metastasis for many cancers, including melanoma, are nearby sentinel lymph nodes (LNs) [6]. As such, sentinel LN biopsy is a common procedure to diagnose and stage melanoma progression [7,8]. Sentinel LNs are often the primary site of metastasis due to tumor cell-st
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It is well established that transcription factors
2021-11-09
It is well established that transcription factors are the major key players in regulating the transcriptional state of the targeted gene. 15 TFs were found in the present study, which were predicted to have the binding affinity with the EZH2 promoter region. Out of these, GCF, AP-2 and Sp1 were most
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The top panel of Fig depicts the
2021-11-09
The top panel of Fig. 3 depicts the average number of planaria visible during each observation for all cohorts in the group testing following light exposure. Although there was considerably more variability than in the light-exposure conditions, a t-test showed no significant difference in count bet
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Importantly HDACi mediated effects are cell and HDAC specifi
2021-11-08
Importantly, HDACi-mediated effects are cell and HDAC specific; different effects and outcomes have been observed in different cell types, targeting different HDAC isoforms. While HDACi exhibit a strong proapoptotic potential in human leukemia psoralen mg 19, 20, 21, 22, they have a limited ability
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In conclusion three heat stable cyclic peptides guanylin uro
2021-11-08
In conclusion, three heat-stable cyclic peptides, guanylin, uroguanylin and renoguanylin are expressed in the intestine and kidney of the European eel, Anguilla anguilla. Their physiological functions are likely to be mediated, at least in part, by two isoforms of the guanylate cyclase type C recept
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Acute in vivo experiments were performed in
2021-11-08
Acute in vivo experiments were performed in normoglycemic 129SVE mice to confirm GPR119 activation and corresponding Z-VDVAD-FMK control. GIP release was utilized as a biomarker for target receptor engagement and plasma GIP levels were measured 45min after oral dosing (). Both 3 and 10mg/kg produce
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We did however observe that niacin treatment impaired
2021-11-08
We did, however, observe that niacin treatment impaired DC accumulation in skin-draining lymph nodes (Fig. 2). Attenuated adaptive immunity, assessed using a contact hypersensitivity assay (Fig. 4), was observed, as would be expected from impaired DC accumulation in lymph nodes, though other mechani
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Glycine regulates several brain functions and glycine transp
2021-11-08
Glycine regulates several brain functions and glycine transporters significantly contribute in such processes. In previous work we reported calpain sensitive regions in N-terminal domains of GlyT1a and GlyT1b (Baliova and Jursky, 2005). Here we show that distal part of glycine transporter GlyT1C-ter
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Free fatty acid receptor FFAR also
2021-11-08
Free fatty nmda receptor antagonist receptor 1 (FFAR1, also known as GPR40) belongs to the family of G protein-coupled receptors (GPCRs) and was de-orphanized in 2003 as a receptor for medium-to long-chain free fatty acids (FFAs) [9,10]. Mainly expressed in beta cells of pancreatic islets, GPR40 ca
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Both anxiety like behavior and
2021-11-08
Both anxiety-like behavior and sucrose preference/intake were reduced in GPR40/FFAR1 KO male mice, while social behavior was normal in KO mice. These findings indicate that brain GPR40/FFAR1 is involved in the modulation of anxiety- and depression-like behavior in rodents. Previous studies have demo
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br Materials and methods br Results
2021-11-08
Materials and methods Results Discussion Acknowledgments This work was financially supported by the University of Tehran, Iran. The authors thank all the teams who worked on the experiments and who provided technical assistance in the laboratory during this study. We also thank the anony
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Growth hormone secretagogue receptor GHSR is a member
2021-11-08
Growth hormone secretagogue receptor (GHSR) is a member of G-protein-coupled receptor family [3]. GHSR is predominantly expressed in human pituitary, rhypothalamus and hippocampus [4]. GHSR is also expressed in peripheral tissues including lungs, liver, kidney, and adrenal gland. In cardiovascular s
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A comparison of our results with
2021-11-08
A comparison of our results with literature data on the action of pregnane and androstane steroids on the functional activity of NMDAR, GABAAR and GlyR enables us to draw the following conclusions. First, androstane steroids (with no substituents at C-17) at a concentration up to 50 μM do not affect
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