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In this review we aim to provide a comprehensive
2021-12-02
In this review, we aim to provide a comprehensive understanding of: 1) how AT-resident CD4+ T cell subpopulations regulate the metabolic status of AT; and 2) how adipocytes as antigen presenting cells to modulate the activities of CD4+ T cell subpopulations in AT. Under condition with obesity, ad
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Three main transport systems are involved in solute loss and
2021-12-01
Three main transport systems are involved in solute loss and red cell dehydration (summarised in Fig. 1: Lew and Bookchin, 2005): the deoxygenation-induced cation conductance (sometimes termed Psickle), the Ca-activated K+ channel (or Gardos channel) and the KCl cotransporter (KCC). Psickle is activ
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A-443654 Recent studies have elucidated a profound role for
2021-12-01
Recent studies have elucidated a profound role for FFA4 in modulation of metabolism and energy utilization as well as endocrine and immune function, and as a consequence, have thrust FFA4 to the forefront of drug discovery efforts. For example, activation of FFA4 by fatty A-443654 or synthetic liga
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Over the last years the signaling
2021-12-01
Over the last years, the signaling pathways initialized by fibroblast growth factors (FGFs) are found to be important for progression and development of several cancers11., 12., 13., 14.. To the best of our knowledge, currently 18 FGFs are identified in human genome, which regulated by four transmem
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The inhibitory activities of the
2021-12-01
The inhibitory activities of the compounds with the modification of the amino group against human liver FBPase are summarized in . Replacement of the amino group of with hydrophobic substituent such as a methyl group () led to a substantial loss of activity (IC=995nM). Similarly, replacement with ha
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Although ALPS type is very rare with few published cases
2021-12-01
Although ALPS type 0 is very rare with few published cases, we herein report the clinical and immunogenetic characteristics of two additional unrelated patients from highly inbred North African population. Both patients present two rare splicing defects mechanisms in FAS gene inducing the skipping o
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According to previous methods several mobile phase compositi
2021-12-01
According to previous methods, several mobile phase compositions and gradient programmes were assayed to get the best resolved peaks for HA and MHA [12], [13], [24]. Considering the slightly structural differences of the analytes, a mobile phase consisting in two eluents of different polarity and pH
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br Heme oxygenase inhibitors Historically the
2021-12-01
Heme oxygenase-1 inhibitors Historically, the first class of competitive HO-1 inhibitors was represented by MPs, heme analogs in which the central iron Dihydrodaidzein of heme is exchanged by another element, such as zinc, cobalt, tin, or chromium. These molecules compete with heme for binding to
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These agents can be divided
2021-12-01
These agents can be divided into three categories based upon the therapeutic agent conjugated to the antibody; the most frequently explored are ADCs using a cytotoxic agent to be delivered directly to the tumor site. The second class has not been broadly used and consists of radionucleotides (Wong e
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SP600125 Carbon monoxide another key product from the breakd
2021-12-01
Carbon monoxide, another key product from the breakdown of heme by HO-1, also plays an important role in the vasculature. Like NO, CO is endogenously derived from the endothelium [68] and can weakly activate sGC by binding to its heme moiety [69]. CO was found to have vasodepressor activity in rats
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We have shown previously that activation of the TGF
2021-12-01
We have shown previously that activation of the TGFβ/Smad signaling pathway in keratinocytes regulates dihydrofolate reductase inhibitor cytoskeleton organization via non-genomic and genomic mechanisms and that RhoB gene is a target of Smad proteins [12,13]. Although the role of RhoB in early non-g
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ML-291 br Introduction The Ras superfamily of small GTPases
2021-12-01
Introduction The Ras superfamily of small GTPases is composed of more than 150 protein members involved in a wide variety of biological processes, such as proliferation, differentiation, cytoskeletal organization, and protein trafficking [1]. The Ras superfamily proteins act as molecular switches
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One of the most common dietary approaches against
2021-12-01
One of the most common dietary approaches against obesity-associated diseases is the increase in the consumption of ω3 polyunsaturated fatty acids [18], [19]. Since seminal paper by Bang and Dyeberg in which the low prevalence of coronary heart disease among the Inuit was associated with the high ma
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We suggest that the FRET enhancement observed when
2021-12-01
We suggest that the FRET enhancement observed when the modified mD1 protein containing Acd at position 28 was excited at 260nm (), may differ from the diminution in fluorescence observed following excitation at 280nm due to the excitation of different transitions in Trp (i.e., the L and L transition
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br Materials and methods br
2021-11-30
Materials and methods Results Discussion Although large-scale purification of homogeneous and functional membrane proteins is challenging, it is essential for biochemical, biophysical and structural characterization. This is particularly true for human P-gp, as its atomic structure has only
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