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One of the most common
2022-01-19
One of the most common dietary approaches against obesity-associated diseases is the increase in the consumption of ω3 polyunsaturated fatty acids [18], [19]. Since seminal paper by Bang and Dyeberg in which the low prevalence of coronary heart disease among the Inuit was associated with the high ma
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For some agonists these stable GPR responses were resistant
2022-01-19
For some agonists, these stable GPR119 responses were resistant to washing. Thus, sustained activation could continue, for at least a number of hours, even after removal of free agonist. These data are consistent with reports for other GPCR systems that do not desensitize (Calebiro et al., 2009, Fer
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We tested this hypothesis with two experiments In the
2022-01-19
We tested this hypothesis with two experiments. In the first experiment OVX monkeys implanted with an E2 TCS 2002 (this results in LH levels similar to the level during the follicular phase) were treated with daily injections of letrozole for 1 week and then EB was injected systemically mimicking t
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EAAT glutamate uptake is driven by the co transport
2022-01-19
EAAT glutamate uptake is driven by the co-transport of three sodium ions and one proton, as well as the counter-transport of one potassium ion (Fig. 1B). This complex stoichiometry frees up enough energy to permit Chidamide of glutamate into the cell against a steep concentration gradient. Addition
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We report on four affected children from two unrelated
2022-01-19
We report on four affected children from two unrelated consanguineous special health care needs with moderate to severe ID associated with epilepsy and variable neuropsychiatric features. Using whole-exome sequencing, we identified homozygous missense variants in SLC45A1 (OMIM: 605763), which codes
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br Conflict of interest statement br Acknowledgments br Intr
2022-01-19
Conflict of interest statement Acknowledgments Introduction Hedgehog (Hh) signaling controls key steps of development in most tissues and organs of invertebrates and vertebrates (Briscoe and Therond, 2013, Ingham et al., 2011, Wilson and Chuang, 2010). The unique cellular composition and mo
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br Genetic manipulation variation of the ghrelin system and
2022-01-19
Genetic manipulation/variation of the ghrelin system and alcohol-related outcomes Genetic manipulation of the ghrelin system (either the peptide or the receptor gene) via knockout rodent models has provided further insight into the role of this system in alcohol seeking and consummatory behaviors
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br Conclusion In the present study
2022-01-19
Conclusion In the present study, we found that the majority of commercially available antibodies and antibody-based tools against galanin and its receptors that we tested do not meet validation requirements. Therefore, critical validation of these tools by the user is essential before being used
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These reports have gradually established G quadruplex bindin
2022-01-19
These reports have gradually established G-quadruplex binding small molecules as promising anti-cancer therapeutic agents. Besides the stabilization of G-quadruplex structures, some of these molecules also serve as diagnostic probes and sensors for G-quadruplexes in vitro and in vivo. Of these, Thio
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br Results br Discussion The inflammasome consists
2022-01-19
Results Discussion The inflammasome consists of the sensor molecule nucleotide oligomerization domain (NOD)-like receptors (NLRs), the adaptor protein ASC, and the Quetiapine synthesis molecule CASP1 (Guo et al., 2015). Among the different types of inflammasome, the NLRP3 inflammasome require
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br Materials and methods br Acknowledgments We are grateful
2022-01-19
Materials and methods Acknowledgments We are grateful for financial support from the National Natural Science Foundation of China (Grants No. 81661148046 and 81773762, China) and the “Personalized Medicines—Molecular Signature-based Drug Discovery and Development”, Strategic Priority Research
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br Conclusion In conclusion rats
2022-01-19
Conclusion In conclusion, rats in this model of HELLP syndrome demonstrated increased placental and circulating FasL and increased placental Fas when compared to NP rats. Administration of an ETA receptor antagonist to HELLP rats tended to decrease circulating FasL and placental Fas, while not af
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br Acknowledgements The authors have
2022-01-19
Acknowledgements The authors have no ethical conflicts to disclose. The authors have no conflicts of interest to declare. This work was funded by the Research Council of Lithuania. Introduction This paper studies whether there is a causal influence of the risk-taking incentives provided by op
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br Conflict of interest br Introduction Colorectal
2022-01-19
Conflict of interest Introduction Colorectal cancer (CRC), characterized by high prevalence in elderly people, is one of the most common cancers of digestive tract. CRC severely affects human health and causes enormous social and economic burdens [[1], [2], [3]]. Although public health awarene
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Development of few more dihydroxy pyrimidine and N
2022-01-19
Development of few more dihydroxy-pyrimidine and N-methylpyrimidone analogues as HIV-integrase inhibitors was attempted involving substitution of variety of five- and six-membered rings via the introduction of a simple methyl substituent in the α-position of the C-2 side chains in order to improve p
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