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Our results demonstrated that most of the HUA
2022-01-29
Our results demonstrated that most of the HUA rings incubated with 100 μM TBT do not have the capacity to contract in the presence of 5-HT or exhibit very low contractions in comparison to the control. Only 23.3% of the HUA rings were able to contract. These results seem to indicate that there may b
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br Conclusion br Acknowledgements This study
2022-01-29
Conclusion Acknowledgements This study was supported by the China Postdoctoral Science Foundation (No.2015M581817), the National Research Council of Science and Technology Support Program (2015BAD03B05-06), and the Priority Academic Program Development of Jiangsu Higher Education Institutions
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br STAR Methods br Acknowledgments We thank Prof Y
2022-01-29
STAR★Methods Acknowledgments We thank Prof. Y. Tomari at the University of Tokyo for experimental advice and K. Hanada for technical assistance. This research was supported by Grants-in-Aid for Scientific Research on Innovative Areas “Nascent Chain Biology” (JP15H01548 and JP17H05677 to T.I. a
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In contrast to RhoA Rac and Rap which
2022-01-29
In contrast to RhoA, Rac1 and Rap1 which are stimulated by platelet activators and inhibited by NO/PKG, the GTPase ADP-ribosylation factor 6 (Arf6) is regulated in the reverse way. Platelet agonists like thrombin, collagen, or ADP, reduce Arf6-GTP levels, whereas NO and PGI2 oppose this reduction [1
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As natural ligands of GPR
2022-01-29
As natural ligands of GPR120, several long chain polyunsaturated fatty acids (Lc-PUFAs) have been demonstrated to modulate the 3T3-L1 adipogenic differentiation. However, the effects of the Lc-PUFAs are inconclusive. DHA is shown to inhibit, promote or even not affect the differentiation of preadipo
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br Funding This work was supported
2022-01-29
Funding This work was supported by grants of the National Academy of Sciences of Ukraine within the programs “Molecular and cellular biotechnologies for medicine, industry and agriculture” (#35-2018), “Scientific Space Research for 2018-2022” (#19-2018), “Smart sensory devices of a new generation
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Tight junctions regulate the transfer of
2022-01-29
Tight junctions regulate the transfer of ions as well as small molecules across endothelial barriers (Li et al., 2015). We also investigated whether resistin affects tight junctions, which play an important role in the conformation of polarized endothelial barriers (Matsuzaki et al., 2010). A previo
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br Introduction Major depressive disorder MDD is
2022-01-29
Introduction Major depressive disorder (MDD) is a disease with poorly recognized etiology. Currently used antidepressant drugs, which mainly affect synaptic neurotransmitter levels, show full clinical efficacy in only one third of patients (Rush, 2007). Thus it is now generally accepted that the
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The role of the ER
2022-01-29
The role of the ER22/23EK variant which is associated with relative resistance to GC, as shown by a reduction of transactivating capacity in vitro and less suppression of Go 6976 levels after 1mg DST in vivo. Relative GC resistance associated with the ER22/23EK polymorphism might protect from the d
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Neovascularization upon IMQ treatment was observed
2022-01-29
Neovascularization upon IMQ treatment was observed to different degrees in WT and GAL3-KO mice, whereas the increase in vascular endothelial growth factor mRNA levels was genotype independent. Because we observed lower levels of the cytokines IL-17A, IL-22, IL-23, and TNF-α in IMQ-treated skin of GA
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br Materials Aspergillus oryzae GS U mg solid was
2022-01-29
Materials Aspergillus oryzae βGS (8.4 U mg−1 solid) was obtained from Sigma-Aldrich Chemicals Co. (USA). o-Nitrophenyl β-d-galactopyranoside (ONPG), sodium carbonate, zinc chloride, manganese chloride, calcium chloride and potassium chloride were procured from Sisco Research Laboratories (SRL), M
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The ability of GPX and other selenoproteins
2022-01-28
The ability of GPX4 and other selenoproteins to be selectively induced by ferroptotic stimuli suggests that the stress-induced increase in the transcription of a number of putative, “antioxidant” selenoproteins is an adaptive homeostatic, but insufficient response to prevent cell death in the face o
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br Expression and Purification of LSD
2022-01-28
Expression and Purification of LSD1 Proteins In Vitro Enzymatic Assays Analysis of LSD1 Demethylase Activity Acknowledgments Conflict of Interest Statement: Y.S. is a cofounder of Constellation Pharmaceuticals, Inc. and is a member of its scientific advisory board. Y.S. is also a consu
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Literature review suggests a strong
2022-01-28
Literature review suggests a strong presence of central histaminergic transmission in the price scd areas targeted by caffeine to induce its behavioral actions. Interestingly, it is reported that caffeine administration increases the histamine neuronal activation and release of histamine in the brai
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br Introduction Adenosine triphosphate ATP is an organic mol
2022-01-28
Introduction Adenosine-5′-triphosphate (ATP) is an organic molecule (nucleoside triphosphate) which consists of adenine, ribose, and three phosphoric Quercetin residues. ATP serves as a temporary carrier of energy in all living cells, so it is a common substance in any organism. In the cells, ne
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