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SB431542 br Methods br Results br Discussion Previous work
2022-04-08
Methods Results Discussion Previous work by the Hirano group investigated the effect of GIP in murine atherosclerotic models and found infusion of GIP (1–42) by osmotic mini-pumps to decrease lesion size after 4 weeks in non-diabetic as well as in diabetic ApoE−/− mice [8], [9]. Mechanistic
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The general aim of our in
2022-04-08
The general aim of our in vitro experiments was to analyze the patterns of ghrelin and GHSR-1a expression in the mammary glands of dairy goats during pregnancy and to examine the direct effect of ghrelin on cell proliferation in cultured MECs of pregnant dairy goats. For this purpose, we cultured go
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Berberine hydrochloride Though regulation of ghrelin interac
2022-04-08
Though regulation of ghrelin interaction with GHSR has not been described previously, a precedent for a similar regulatory mechanism exists in the form of the interaction between Agouti-Related Protein (AgRP) and melanocortin receptor subtypes MC3R and MC4R (Ollmann, 1997). AgRP is produced by hypot
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The role of cell to cell interactions in coordinating the
2022-04-07
The role of cell-to-cell interactions in coordinating the cells’ behaviour to ensure an appropriate anterior pituitary hormone response is receiving increasing attention. Anterior pituitary luteolin interact with neighbouring cells through junctional complexes. As their name implies, the complexed a
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In the intestine ethanol exposure
2022-04-07
In the intestine, ethanol exposure can change the composition of gut microbiota and promotes the growth of intestinal gram-negative bacteria, which results in the accumulation of endotoxins such as, LPS. Ethanol also impacts the integrity of the gastrointestinal mucosal barrier, increasing intestina
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epothilone Recent evidence indicates that prolonged vasocons
2022-04-07
Recent evidence indicates that prolonged vasoconstriction of conductance and resistance arteries involves VSMCs epothilone polymerization, through activation of small GTPases [4] and a subsequently transition to a more solid rheology [5]. Actin polymerization occurs in two steps, nucleation and elon
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br Materials and methods br
2022-04-07
Materials and methods Results Discussion ERK5 signaling and its regulation has gained focus in recent years specially in the subject of cardiovascular biology, where this kinase plays a key role in angiogenesis and maintenance of blood vessel integrity [18,20,34,35]. The signaling pathways
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Syt itself does not catalyze
2022-04-07
Syt1 itself does not catalyze lipid mixing and membrane fusion. Rather, the pairing of vesicular and target membrane SNAREs into complexes serves to pull bilayers together to drive fusion; Ca•syt1 accelerates these fusion reactions so that they occur on rapid timescales in a manner that is precisel
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This study has some limitations The RDS technique
2022-04-07
This study has some limitations. The RDS technique was not effective for the population of MSM from Natal, as it has not reached the sample size initially calculated. Few seeds had enough waves to disperse the sample and make it closer to a probabilistic sample, even with all efforts from the resear
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br Acknowledgements and disclosures This work was
2022-04-07
Acknowledgements and disclosures This work was supported in part by the National Institutes of Health (R01 HL-131673-01A1) and the Veterans Administration (BX-002539-01), United States. The authors have nothing to disclose concerning any conflict of interest. Introduction Adaptations are ofte
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IGF-1, human recombinant GPR agonistic activity was evaluate
2022-04-06
GPR119 agonistic activity was evaluated for the human GPR119 receptor in a cell-based cAMP assay. The results expressed the potency as EC values and the inherent activity (IA) as percentages which were compared to the test compound with oleoylethanolamide (OEA), an endogenous ligand of GPR119 (defin
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Methods br Results br Discussion The
2022-04-06
Methods Results Discussion The current study is the first to specifically investigate the role of hepatic GPR109A and GPR109B on HDL metabolism and response to niacin therapy. While niacin raises HDL-C levels in humans, it has been reported by others [20], [36] and confirmed by us here that n
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These differences have led to the recognition
2022-04-06
These differences have led to the recognition that the extent to which transport contributes to shaping postsynaptic signals likely reflects a balance between the density of transporters and the amount of l-glutamate in the synaptic cleft. Consequently, those synapses exhibiting the characteristics
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To maintain low Glu concentrations in the synaptic cleft bel
2022-04-06
To maintain low Glu concentrations in the synaptic cleft below the affinity of its receptors, this amino perhexiline receptor is rapidly removed from the extracellular space by a family of sodium-dependent high-affinity transport systems located mainly in the plasma membrane of perisynaptic astrocy
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There are two ways to transport FFAs into cells First
2022-04-06
There are two ways to transport FFAs into cells. First by passive diffusion. Second as the putative long-chain fatty WAY-100635 maleate salt synthesis transporters are proposed, CD36 the plasma membrane-associated fatty acid-binding protein (FABPpm) and fatty acid transport proteins (FATP) [11], wh
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