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Abnormal expression and higher activity
2022-05-18
Abnormal expression and higher activity of GLO I have been detected more in various tumor CKI 7 dihydrochloride than in normal cell samples., , , , , , , Among cancer cell lines, lung carcinoma cells frequently showed higher GLO1 activity. Human NSCLC cell line NCI-H522 cells possess high activity a
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Lamina II SG spinal cord neurons play an important role
2022-05-18
Lamina II (SG) spinal cord neurons play an important role in regulating nociceptive input from the periphery [20,21]. Moreover, lamina II neurons are concentrated with glycinergic or GABAergic inhibitory interneurons. Therefore, it is possible that β-alanine might modulate nociceptive transmission i
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br Funding This work was supported by
2022-05-18
Funding This work was supported by the Deutsche Forschungsgemeinschaft (SFB766 and GRK1708). Conflict of interest Acknowledgements Introduction Hepatitis C virus (HCV) infection is a global problem affecting about 3% of the world’s population [1], [2]. Mother-to-child transmission of HC
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The CO chemosensitivity of the LH PFA
2022-05-18
The CO2 chemosensitivity of the LH/PFA has been shown to be dependent on sleep-wake states (B.S. Deng et al., 2007; Dias et al., 2010, 2009; Li et al., 2013). In this context, it was demonstrated that focal acidification of the LH/PFA, by microdialysis of acidic artificial cerebrospinal fluid (aCSF)
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The unique mechanism of EAAT anion channel gating
2022-05-18
The unique mechanism of EAAT anion channel gating results in neuronal or glial anion conductances that follow changes in substrate concentrations and thus allow feedback control of glutamate release (Wersinger et al., 2006) or modification of GABAergic postsynaptic currents by glutamatergic signals
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That MSCs release IL upon LPS stimulation or other stressful
2022-05-18
That MSCs release IL-6 upon LPS stimulation or other stressful stimuli like H2O2 [43] is well-documented [44]. However, there are conflicting reports on the potential effects of this cytokine in stroke. Some studies have found that the external administration of IL-6 in ischemic animal models leads
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br Discussion In the present
2022-05-18
Discussion In the present study, we have demonstrated the effect of a high-fat diet upon wild-type and glut3 pregestational female phenotype and shown that it leads to obesity due to an increase in white adipose tissue contributing to the overall fat mass. Despite this observed obesity along with
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A key limiting factor in the
2022-05-18
A key limiting factor in the semi-quantitative analysis of changes in the nuclear-to-cytoplasmic distribution of glucokinase is the large intercellular heterogeneity of Estradiol of glucokinase in both isolated hepatocytes in vitro and also in liver in vivo[13], [23], [24], [26], [36]. This necessi
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br Conflict of interest statement br Acknowledgements This w
2022-05-18
Conflict of interest statement Acknowledgements This work was supported by the National Health and Medical Research Council of Australia (NHMRC) (project grants [1061044], [1065410] and [1126857], and NHMRC program grant [1055134]); P.M.S. and A.C. are NHMRC Principal and Senior Principal Rese
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The effects of GHS R a blockade on
2022-05-18
The effects of GHS-R1a blockade on alcohol-related outcomes have been examined in numerous preclinical experiments, utilizing various GHS-R1a antagonists (JMV 2959, [D-Lys3]-GHRP-6, BIM 28163) and rodent species (prairie vole, mouse, rat). In spite of methodological differences, the results consiste
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OCA has recently been approved for the
2022-05-17
OCA has recently been approved for the treatment of patients with PBC and is under study for diseases such as NASH, PSC and biliary atresia [30], [49]. Up to now, the beneficial effects of OCA have been related to its anti-cholestatic, anti-inflammatory and anti-fibrotic properties. We have here rep
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By measuring the accumulation of
2022-05-17
By measuring the accumulation of unprenylated Rap1a as a surrogate marker for the inhibition of FPPS [8], [9], [10], [11], we found that upregulation of FPPS expression in Hela cells reduced the accumulation of unprenylated Rap1a in response to 24h' treatment with 0–50μM ZOL. As expected, cells cult
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Current guidelines for thromboprophylaxis recommend the use
2022-05-17
Current guidelines for thromboprophylaxis recommend the use of vitamin K antagonists (eg, warfarin), low-molecular-weight heparin (LMWH), or indirect inhibitor of factor Xa . Aspirin is also used for thromboprophylaxis in patients undergoing orthopedic procedures , . The efficacy and safety of LMWH
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It should be noted that the current studies were
2022-05-17
It should be noted that the current studies were performed in female rats. Although the oestrous cycle has been shown to modulate inflammatory processes in the periphery, data from our group has demonstrated that the phase of the oestrus cycle does not significantly alter TLR3-mediated neuroinflamma
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Recently IL was also identified as an important
2022-05-17
Recently, IL-10 was also identified as an important mediator of collagen deposition in the development of HF [64,65]. It was shown, that this cytokine activates macrophages found in the hearts of mice suffering from diastolic dysfunction in the autocrine manner [64]. In response, specific subset of
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