• br Experimental Procedures br Author Contributions br Acknow

  2018-11-08

  

  Experimental Procedures Author Contributions Acknowledgments We thank Clive N. Svendsen for providing the human fetal cortical neural stem cells, Rachel Harker and Scott Muller for exceptional primate husbandry, Cedric Bardy and the Salk Institute for providing the BrainPhys medium used in

• We also showed that the transient suppression of Nanog

  2018-11-08

  

  We also showed that the transient suppression of Nanog by siRNA annulled the self-renewal capacity and tumorigenic activity of GSCs and induced the differentiation of these cells. Recent evidence suggested a shared genomic fingerprint between ESCs, cancer cells, and cancer stem cells. Nanog, Sox2, a

• Our observations are consistent with previous findings

  2018-11-08

  

  Our observations are consistent with previous findings in vivo that Ahr expression is silenced at the 2-cell stage, becoming again detectable in late blastocysts (Peters and Wiley, 1995; Dey and Nebert, 1998; Wu et al., 2002) and in most developing organs during post-implantation development (Abbott

• In summary we confirm that HB F CD and HB

  2018-11-08

  

  In summary, we confirm that HB1.F3.CD and HB1.F3.CD.IFN-β buy olda selectively migrated toward breast cancer cells. This is likely due to various chemokines expressed by the tumor cells and their cognate receptors expressed on the stem cells, such as SCF/c-kit and VEGF/VEGFR2, respectively. The via

• chenodeoxycholic acid In conclusion a D suspended MC rocker

  2018-11-08

  

  In conclusion, a 3D suspended MC rocker platform, similar to a wave bioreactor, that integrates both hESC expansion and CM differentiation has been developed and shown to be capable of producing the highest quantities of CMs to date (190.5±58.8×106 cTnT positive CM/production run; 31.75±9.74 cTnT po

• Positive selection via magnetic sorting for CD increased the

  2018-11-08

  

  Positive selection via magnetic sorting for CD133 increased the CD133+ proportion of the XF Shef6 hNSCs from 17% to 82%. Interestingly, the CD34+ proportion of the Shef6 hNSCs was measured at less than 5%, as detected by flow cytometry, in both the non-sorted and CD133+/CD34− sorted hNSCs, which may

• Results from several recent studies in lower

  2018-11-08

  

  Results from several recent studies in lower vertebrates are consistent with an important role for ECM-derived signals for heart regeneration (Fig. 2). Fibronectin, a major component of the ECM, is secreted by epicardial Bindarit Supplier and deposited at the injury site after cardiac injury in zebr

• Yamazaki et al showed that PTCH receptor expression was obse

  2018-11-08

  

  Yamazaki et al. showed that PTCH receptor expression was observed in cultured human peripheral blood-derived endothelial progenitor cells (EPCs) but not in mature endothelial cells (Yamazaki et al., 2008), suggesting that SHh might have a certain effect on human EPCs and CD34+ cells. Indeed, recent

• Mammalian muscle differentiation is governed by the expressi

  2018-11-08

  

  Mammalian muscle differentiation is governed by the expression of a series of master regulatory transcription factors, collectively called myogenic regulatory factors (MRFs) (Bentzinger et al., 2012; Molkentin and Olson, 1996). Proliferating myoblasts start expressing MRFs, i.e. MyoD, myogenin, MRF4

• Our experiments suggest that Runx may be a useful

  2018-11-08

  

  Our experiments suggest that Runx1 may be a useful target to manipulate in order to direct the endogenous NSPC proliferative response toward maximal neurogenesis following traumatic wst-1 assay injury. Runx1 over-expression has been demonstrated to facilitate neuronal differentiation and long-range

• In the following we provide an overview

  2018-11-08

  

  In the following we provide an overview on recent applications of designer nucleases in human PSCs and on the Metabolism Compound Library of possible targeting and selection strategies (Supplemental Table 1). Thereby, Fig. 1 highlights the key parameters which have to be considered before starting g

• The leading approaches to this are DA

  2018-11-08

  

  The leading approaches to this are DA cell transplantation, or stimulating endogenous DA neurogenesis, in either SNc or its efferent target the dorsal striatum. Despite progression of cell transplantation to clinical trials, it is still not widely available due to lack of a standardized and morally

• hedgehog pathway br Acknowledgement Our work is supported

  2018-11-08

  

  Acknowledgement Our work is supported by research grants from the Agence Nationale de la Recherche (ANR; projects PLURABBIT no. PCS-09-GENM-08 and ORYCTOGENE no. ANR-12-RPIB-0013), European Cooperation in Science and Technology (COST) Action (Rabbit Genome Biology (RGB)-Net no. TD1101), HyPharm,

• As shown in Figure D

  2018-11-08

  

  As shown in Figure 1D, we propose an optimized strategy for promoting osteoblast differentiation from mESCs under chemically defined conditions. This strategy consists of three phases: the maintenance of mESCs using 2i plus leukemia inhibitory factor (LIF) culture, mesoderm induction by CHIR in comb

• We have found a rare population

  2018-11-08

  

  We have found a rare population of pNSCs in the adult mammalian brain (termed AdpNSCs). We isolated cells from the adult periventricular region that generate clonally derived, self-renewing, and multipotent colonies in vitro in the presence of LIF. These LIF colonies can be passaged to give rise to

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