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The significant SNPs lie in non coding
2018-11-14

The significant SNPs lie in non-coding regions, as is common in GWAS where ~64% of identified SNPs lie in enhancer regions (Hnisz et al., 2013). Gene enhancer elements are noncoding segments of DNA involved in regulating transcriptional programs (Corradin and Scacheri, 2014). Their location is predi
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In the present study we took advantage
2018-11-14

In the present study, we took advantage of the IVF procedure to focus on the imprinting alteration in oocyte before fertilization. Analysis in human showed that expression of IGF2, an acknowledged maternal imprinted gene responsible for β-cell function, was increased in oocytes from patients with hy
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The current reporter assay used luciferase ZIKV
2018-11-14

The current reporter assay used luciferase ZIKV and DENV-2. It is ideal to expand the reporter viruses to DENV-1, -3, and -4. The reporter virus-based neutralization assay could be further expanded to other flaviviruses (Deas et al., 2005; Shustov et al., 2007; Zhang et al., 2016) as well as to othe
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It has been known for some
2018-11-14

It has been known for some 30years now that manifest autoimmune disease is correlated with changes in the glycosylation of antibodies (), and the list of autoimmune diseases with alteration in IgG glycosylation is rapidly growing with increasingly detailed analysis of glycoforms (for a review see ()
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Even if the DP of the
2018-11-14

Even if the DP of the method calculated from this study is >0.99 (DP=0.995, as compared to 0.992 in our previous study (Gits-Muselli et al., 2015)), the distance between P. jirovecii genotypes remains low using our MLP typing method, resulting in a limited number of genetic groups. This low genetic
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br Experimental design materials and methods br Acknowledgme
2018-11-14

Experimental design, materials and methods Acknowledgments This work was supported by Colon Cancer Canada and support for Dr. V. Ho (postdoctoral fellow) was provided by the Canadian Institutes of Health Research Postdoctoral Fellowship. Data These data were collected as described in detai
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Kinematic data were low pass filtered Hz cutoff
2018-11-14

Kinematic data were low-pass filtered (15Hz cutoff; Matlab R2012a), ground reaction force data were low-pass filtered (50Hz cutoff), and internal joint moments were computed using matched filter cutoffs (15Hz). EMG data were band pass filtered (15–300Hz cutoff), full-wave rectified, and low-pass fil
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With respect to the neural processes
2018-11-13

With respect to the neural processes that underlie the impact of body expression on emotional face processing in adults, using face-body compound stimuli Meeren et al. (2005) presented evidence for a very rapid influence of emotional incongruence between face and body. Specifically, in this ERP stud
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While the current discussion largely restricts itself to neu
2018-11-13

While the current discussion largely restricts itself to neuroimaging methods that can make spatial inferences, ERP studies of RS have found similar results: while there is evidence of auditory RS involving both temporal and frontal cortices (Dehaene-Lambertz and Dehaene, 1994), ERP studies of visua
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jasplakinolide Developmental changes in the reliance on
2018-11-13

Developmental changes in the reliance on model-based learning might also reflect an increasing capacity to recruit learned cognitive models to guide decisions. Working memory, the ability to maintain mental representations in an active state despite interference, is a key component of model recruitm
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From a network dynamics perspective the amPFC is
2018-11-13

From a network dynamics perspective, the amPFC is part of the midline core components of the DMN and may underlie the evaluation of experiences with a high personal significance (Andrews-Hanna et al., 2010). In a detailed study of the structural and functional changes that occur in the DMN, Supekar
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El discurso de las feministas
2018-11-13

El discurso de las feministas del primer mundo sitúa la clitorectomía no sólo en otro lugar —en África—, sino también en otro tiempo. Un reciente artículo en el Atlantic Monthly sobre la clitorectomía africana afirmaba que “la profesión médica americana había dejado de realizar clitorectomías hace d
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Una de las grandes consecuencias de la II
2018-11-13

Una de las grandes consecuencias de la II Guerra Mundial fue la ulterior Declaración Universal de Derechos Humanos, desarrollada y escrita por profesores, abogados y políticos, muchos de ellos latinoamericanos. Esta acción ha inspirado una agenda global de derechos humanos y ha creado una plataforma
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br Conflict of interest br Acknowledgements Authors would li
2018-11-13

Conflict of interest Acknowledgements Authors would like to thank the financial support of the European Community’s Seventh Framework Programme FP7-SME-2013 “DEMOTOX” – Proposal no 604752, the Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia (Rome, Italy) and the Italian
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To generate energy for nanoscale systems ZnO
2018-11-13

To generate energy for nanoscale systems, ZnO based piezoelectric nanogenerators are an ideal source, especially in the case of small size and low power consumption batteries with a long life time. For a sustainable independent operation, a continuous power source is required and for this type of op
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